
Chlorpheniramine Maleate is available as an FDA-approved commercial product and as a compounded formulation, prepared by Mixlab for veterinary use in dogs and cats. Available by prescription.
The uses and pharmacology described below reflect the FDA-approved labeling for this active ingredient; your veterinarian determines whether and how they apply to your animal's treatment plan.
Chlorpheniramine is a first-generation antihistamine that blocks histamine at the H1 receptor, reducing itching and other allergic signs. On the FDA-approved human label, it is indicated for the relief of allergy symptoms.
In veterinary medicine, chlorpheniramine is used off-label in dogs and cats for mild allergic skin conditions, and is one of the more commonly used antihistamines in cats specifically. This information is not a substitute for veterinary diagnosis, prescribing, or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
Commonly reported effects include sedation or, less commonly in cats, agitation, along with dry mouth and gastrointestinal upset. Use with caution in animals with glaucoma, urinary retention, or heart disease. Check with your veterinarian or pharmacist before giving any human chlorpheniramine product, since some combination products contain other ingredients, like decongestants, that are not appropriate for pets.
Yes. Chlorpheniramine is available only by prescription from a licensed veterinarian.
Both. Mixlab can dispense the FDA-approved commercial product, or compound the active ingredient into an alternative strength or format if your veterinarian determines that better suits your pet's needs. The decision rests with the prescribing veterinarian.
Chlorpheniramine is used to help manage mild allergic skin reactions in dogs and cats, and is commonly used in cats specifically. Your veterinarian determines whether it's appropriate for your pet.
Sedation is the most commonly reported effect. Contact your veterinarian if you notice unusual agitation, difficulty urinating, or behavior changes.




