SMART BUTE (Phenylbutazone/Omeprazole) Powder
SMART BUTE (Phenylbutazone/Omeprazole) is a compounded formulation containing Phenylbutazone/Omeprazole, prepared by Mixlab for veterinary use. Available by prescription.
Powder medications are meant to be mixed into food or treats, not given on their own (since most pets won’t lick up plain powder). The key is to mix it into something tasty so your pet eats the entire dose.
How to Give It:
- Measure the dose using the included scoop or follow the instructions. If you’re unsure how much to give, ask your vet or pharmacist.
- Mix it with a small amount of soft food or treat—like wet food, baby food (meat flavor), peanut butter (xylitol-free), yogurt, or cheese. Use just enough to hide the powder so your pet finishes it all in one go.
- Stir it well to blend the powder in evenly. Add a splash of water if needed to make it smoother.
- Offer it when your pet is a little hungry, and watch to make sure they eat the whole thing.
- If your pet refuses, try something else they love next time. For cats, you can also try smearing the paste on their paw to lick off (only if safe and comfortable).
- For large animals, mix the powder into a small portion of feed with water or molasses, then follow with the rest of their food once they’ve eaten the medicated part.
- Store the powder in a cool, dry place with the lid closed tightly.
Never give powder straight into your pet’s mouth—it can be dangerous if inhaled.
This is a compounded preparation combining the active ingredients listed in the product name. In compounding practice, clinicians may consider a multi-ingredient preparation like this to address more than one aspect of a patient's physiology at once. Your veterinarian determines whether it is appropriate for your animal.
This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
Commonly observed effects of SMART BUTE administration include changes in appetite, loose stools or localized swelling at the site of administration if utilizing injectable forms. Because phenylbutazone can influence renal blood flow, your veterinarian will monitor for signs of kidney health shifts, particularly in patients that are dehydrated or have pre-existing renal concerns. It is important to observe for any signs of "girthiness," behavioral changes during feeding or dark, tarry stools, which should be reported to your veterinarian promptly.
This medication is typically used with extra caution or avoided in patients with known liver or kidney impairment or those with active gastrointestinal ulceration that requires a different clinical protocol. It is also carefully evaluated in breeding, pregnant or lactating mares, as the safety profile for developing foals is a point of professional consideration. Before starting a protocol involving SMART BUTE, ensure your veterinarian has a complete history of all other prescriptions and supplements your horse is receiving, as phenylbutazone may interact with other highly protein-bound medications. Your veterinarian is the right person to design a comprehensive monitoring plan and provide guidance on the necessary duration of use to ensure the management approach remains suitable for your horse's individual health status.
Yes. SMART BUTE is a combination of prescription medications and can only be dispensed by a licensed pharmacy upon receipt of a valid authorization from a licensed veterinarian. Mixlab verifies authorization before dispensing any prescription medication to ensure it meets the specific needs of your horse.
Yes. SMART BUTE is a specialized compounded formulation that integrates phenylbutazone and omeprazole into a single dosage form. Mixlab's compounding team can prepare this medication in various formats—such as flavored oral pastes or powders—when a veterinarian determines that a customized preparation better suits an individual horse's clinical requirements.
Veterinarians discuss the inclusion of omeprazole because NSAIDs like phenylbutazone can sometimes influence the protective lining of the stomach. Omeprazole is included as a proton pump inhibitor to help manage the levels of gastric acid during the period that the horse is receiving musculoskeletal support.
Owners should monitor for subtle behavioral shifts such as a decrease in appetite, slow eating, teeth grinding or discomfort when the cinch or girth is tightened. If you observe any of these changes or if your horse's manure becomes dark or tarry, contact your veterinarian immediately for a clinical evaluation.
