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Sileo Gel

Sileo Gel

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Select Strength: 0.09mg/ml
Select size: 3 mL
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Sileo is an FDA-approved preparation containing Sileo, for veterinary use. Available by prescription.

Dexmedetomidine hydrochloride, commercially available as Sileo, is an alpha-2 adrenoceptor agonist utilized for canine behavioral management. It is a prescription oromucosal gel available for use in dogs, frequently considered in the context of behavioral health for managing noise aversion and situational stress.

The actions described here reflect the product's FDA-approved labeling; your veterinarian determines the appropriate use for your animal.

Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring.

At a pharmacological level, it is used in the context of managing the sympathetic nervous system by inhibiting the release of norepinephrine, providing an approach for managing arousal without profound sedation. Commonly observed effects include behavioral shifts such as temporary lethargy or localized changes like pale gums. Because it influences vascular tone, your veterinarian will monitor for observational signs of cardiovascular status. Owners should wear gloves when applying the gel to the gums and contact their veterinarian promptly with any concerns.

Do I need a prescription?

Yes. Sileo is a prescription medication and requires a valid authorization from a licensed veterinarian. Mixlab ensures all professional standards are met before dispensing.

How is Sileo applied?

Sileo is an oromucosal gel intended to be applied between the dog's cheek and gum. It is important that the gel is not swallowed, as this would manage its effectiveness.

Why is this used for fireworks or thunder?

Veterinarians discuss Sileo because it is used in the context of managing the "fight or flight" response to loud noises. This offers an approach to managing your dog's anxiety during specific environmental triggers.

Should I wear gloves during application?

Yes. It is important to wear gloves to prevent the medication from being absorbed through your own skin. This offers an approach to preventing accidental changes in your own blood pressure.

Will this medication make my dog sleep for hours?

Sileo acts to provide calming effects without the level of sedation associated with injectable versions. Your veterinarian will provide guidance on the expected behavioral shifts.

Mixlab is a licensed veterinary pharmacy dispensing both compounded and commercial medications, operating under the oversight of licensed pharmacists and in compliance with applicable state and federal pharmacy regulations. Compounded medications are prepared in compliance with USP standards and under PCAB-accredited practices. All medications dispensed by Mixlab require a valid prescription from a licensed veterinarian.
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