PredniSOLONE Powder
PredniSOLONE is a compounded formulation containing PredniSOLONE, prepared by Mixlab for veterinary use. Available by prescription.
Powder medications are meant to be mixed into food or treats, not given on their own (since most pets won’t lick up plain powder). The key is to mix it into something tasty so your pet eats the entire dose.
How to Give It:
- Measure the dose using the included scoop or follow the instructions. If you’re unsure how much to give, ask your vet or pharmacist.
- Mix it with a small amount of soft food or treat—like wet food, baby food (meat flavor), peanut butter (xylitol-free), yogurt, or cheese. Use just enough to hide the powder so your pet finishes it all in one go.
- Stir it well to blend the powder in evenly. Add a splash of water if needed to make it smoother.
- Offer it when your pet is a little hungry, and watch to make sure they eat the whole thing.
- If your pet refuses, try something else they love next time. For cats, you can also try smearing the paste on their paw to lick off (only if safe and comfortable).
- For large animals, mix the powder into a small portion of feed with water or molasses, then follow with the rest of their food once they’ve eaten the medicated part.
- Store the powder in a cool, dry place with the lid closed tightly.
Never give powder straight into your pet’s mouth—it can be dangerous if inhaled.
The uses and pharmacology described below reflect the FDA-approved labeling for this active ingredient; your veterinarian determines whether and how they apply to your animal's treatment plan.
Veterinarians most commonly consider prednisolone when a patient is presented with allergic conditions, chronic respiratory challenges or dermatological issues characterized by significant itching and irritation. It is also a frequent point of discussion for the management of immune-mediated conditions, such as autoimmune hemolytic anemia or inflammatory bowel disease, where modulating the body’s immune response is a clinical objective. In feline and equine medicine, prednisolone is often the primary corticosteroid selected because these species may have a limited ability to metabolically convert prednisone into its active form, prednisolone.
At a pharmacological level, prednisolone acts by binding to specific cytoplasmic glucocorticoid receptors. Once bound, this complex moves into the cell nucleus, where it alters gene transcription to inhibit the production of pro-inflammatory cytokines and enzymes. This mechanism modulates vascular permeability and suppresses the migration of white blood cells to areas of tissue stress. Prednisolone also influences the metabolism of carbohydrates, proteins and fats, which shapes its systemic physiological profile. Your veterinarian will determine the appropriate application of prednisolone based on your pet’s species, weight and the specific nature of the immune or inflammatory management plan.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
Commonly observed effects of prednisolone administration include increased thirst (polydipsia), increased appetite (polyphagia) and more frequent urination (polyuria). Some animals may exhibit transient behavioral shifts, such as restlessness or lethargy and localized gastrointestinal changes like vomiting or loose stools. Long-term use is associated with physiological changes including weight gain, a thinning hair coat or a pot-bellied appearance. Because prednisolone can influence blood glucose levels, your veterinarian will monitor for signs of metabolic shifts, particularly in patients with pre-existing conditions like diabetes mellitus.This medication is typically used with extra caution or avoided in patients with known systemic fungal infections, corneal ulcers or significant kidney impairment. It is also carefully evaluated in pregnant animals, as high doses of glucocorticoids have been discussed in the context of developmental changes or the timing of parturition. Before starting a protocol, ensure your veterinarian has a complete history of all other prescriptions and supplements your pet is receiving, as it may interact with non-steroidal anti-inflammatory medications (NSAIDs), certain diuretics or insulin. Your veterinarian is the right person to provide guidance on the necessary tapering protocols used when discontinuing the medication to ensure the patient's adrenal function remains stable. Contact your veterinarian promptly if you observe significant behavioral changes, dark or tarry stools or signs of physical distress.
Yes. Prednisolone is a prescription corticosteroid and can only be dispensed by a licensed pharmacy upon receipt of a valid authorization from a licensed veterinarian. Mixlab verifies all prescriptions before any medication is prepared or shipped to your home.
Yes. While prednisolone is available in various commercial tablet and liquid formats, Mixlab can compound this medication into specialized strengths or flavored dosage forms—such as flavored oral suspensions, chews or treats—if your veterinarian determines a customized preparation better suits your pet's needs. The decision between a commercial and compounded product rests with the prescribing veterinarian.
Veterinarians frequently select prednisolone for cats because feline livers are often less efficient at converting prednisone into its active form. By providing the medication already in the active prednisolone state, your veterinarian can ensure more consistent levels of the medication in your cat's system.
Owners should monitor for increased water consumption and more frequent trips outside or changes in litter box habits. It is also important to observe for any changes in appetite, energy levels or digestive upset, reporting these observations to your veterinarian to ensure the management plan remains appropriate.
