Omeprazole/Cimetidine Powder

Powder medications are meant to be mixed into food or treats, not given on their own (since most pets won’t lick up plain powder). The key is to mix it into something tasty so your pet eats the entire dose.

How to Give It:

1. Measure the dose using the included scoop or follow the instructions. If you’re unsure how much to give, ask your vet or pharmacist.
2. Mix it with a small amount of soft food or treat—like wet food, baby food (meat flavor), peanut butter (xylitol-free), yogurt, or cheese. Use just enough to hide the powder so your pet finishes it all in one go.
3. Stir it well to blend the powder in evenly. Add a splash of water if needed to make it smoother.
4. Offer it when your pet is a little hungry, and watch to make sure they eat the whole thing.
5. If your pet refuses, try something else they love next time. For cats, you can also try smearing the paste on their paw to lick off (only if safe and comfortable).
6. For large animals, mix the powder into a small portion of feed with water or molasses, then follow with the rest of their food once they’ve eaten the medicated part.
7. Store the powder in a cool, dry place with the lid closed tightly.

Never give powder straight into your pet’s mouth—it can be dangerous if inhaled.

This compounded formulation combines omeprazole, a proton pump inhibitor, with cimetidine, an H2-receptor antagonist — two different drug classes. In compounding practice, clinicians may consider a combination like this for a multi-targeted approach. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.

At a pharmacological level, omeprazole acts as a proton pump inhibitor by irreversibly binding to the hydrogen-potassium ATPase enzyme system within the gastric parietal cells. This action suppresses the final step of acid secretion into the stomach lumen. Cimetidine acts as an H2 receptor antagonist by competitively inhibiting histamine at the receptors of the parietal cells. While both medications serve to manage acid levels, they act on different stages of the secretory process. This combination is intended to address the gastric environment through complementary mechanisms, providing a broader profile of acid modulation. Your veterinarian will determine if this specific combination is appropriate based on your horse's history, activity level and diagnostic findings.

This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.

Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.

Commonly observed effects of omeprazole/cimetidine may include mild gastrointestinal changes such as loose stools or transient changes in appetite shortly after administration. Because cimetidine is known to inhibit certain hepatic microsomal enzymes, it may influence the metabolism of other medications. Your veterinarian will monitor for potential medication interactions and may recommend specific timing for administration if your horse is receiving other prescriptions.

This medication is typically used with caution in patients with known liver or kidney impairment, as these systems are responsible for the processing and excretion of the active ingredients. It is essential to provide your veterinarian with a complete history of all other medications and supplements your horse is receiving, as the alteration of gastric pH can influence the absorption of other oral treatments. Always follow the professional guidance provided by your veterinarian regarding the duration of use and any necessary patient monitoring. Contact your veterinarian promptly if you observe significant behavioral changes, persistent diarrhea or any signs of physical discomfort during the administration period.