Neomycin/Polymyxin B/Dexamethasone Ophthalmic Suspension
Neomycin/Polymyxin B/Dexamethasone is a compounded formulation containing Neomycin, Polymyxin B, Dexamethasone, prepared by Mixlab for veterinary use. Available by prescription.
How to Give Your Pet Eye Drops – Suspension Type
Ophthalmic suspensions are eye drops that contain tiny medicine particles mixed in liquid. They may look a bit cloudy or milky—this is normal! The key is to gently shake before use so each drop has the right amount of medicine.
Step-by-Step Guide:
- Wash Your Hands: Start clean to protect your pet’s eyes.
- Shake the Bottle: Gently invert or shake the bottle to mix the suspension before each use.
- Get Your Pet Comfortable: Sit your dog or wrap your cat in a towel to keep them still. A second person can help steady the head.
- Clean the Eyes (if needed): Use a damp cotton ball to remove discharge—use a clean one for each eye.
- Position for Application: Tilt your pet’s head up. Use your fingers to gently pull the lower eyelid down (or lift the upper one).
- Apply the Drops: Hold the dropper close (but don’t touch the eye) and squeeze the prescribed number of drops. The drops may look a little cloudy—totally normal for suspensions.
- Let Your Pet Blink: Blinking spreads the medicine evenly across the eye.
- Repeat for the Other Eye: Follow the same steps if both eyes are being treated.
- Prevent Rubbing: Keep your pet calm for a moment so the drops absorb.
- Storage & Tips: Shake before every use, wait 5–10 minutes between different eye meds. Store as directed (room temp or fridge—check your label) and recap tightly after use
This compounded formulation combines active ingredients from different drug classes: neomycin, an aminoglycoside antibiotic; polymyxin B, a polymyxin antibiotic; and dexamethasone, a corticosteroid. In compounding practice, clinicians may consider a multi-ingredient preparation like this to address more than one aspect of a patient's physiology at once. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.
This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
At a pharmacological level, the antibiotics are considered to influence the bacterial population while dexamethasone is considered to modulate the inflammatory response. Commonly observed effects include localized changes such as mild redness, temporary squinting or discharge. Because the formulation contains a corticosteroid, your veterinarian will monitor for observational signs of steroid influence. Ensuring the eardrum is intact is a high-priority clinical consideration before otic use. Owners should monitor for any behavioral shifts and contact their veterinarian promptly.
Yes. This combination requires a valid prescription from a licensed veterinarian before it can be dispensed. Mixlab verifies all legal authorizations before any medication is prepared or shipped.
Yes. Mixlab specializes in compounding neomycin, polymyxin B and dexamethasone into customized sterile eye drops or otic suspensions tailored to the specific needs of your pet.
Veterinarians may consider combining these ingredients so the preparation can act through more than one mechanism at once — here, it brings together antibacterial and anti-inflammatory actions in one preparation. Your veterinarian determines whether this multi-targeted approach is appropriate for your pet.
Steroids are typically avoided in pets with corneal ulcers as they may influence the healing process. Your veterinarian will perform a professional exam to ensure this management approach is appropriate.
You should monitor for observational signs like decreased redness and improved comfort. If you notice increased squinting or cloudiness, contact your veterinarian immediately for a clinical review.
