Gentamicin/Polymixin B/Dexamethasone Otic Suspension
Gentamicin/Polymixin B/Dexamethasone is a compounded formulation containing Gentamicin, Polymixin B, Dexamethasone, prepared by Mixlab for veterinary use. Available by prescription.
How to Give Otic Suspension Ear Medication
Otic suspension are creamy ear meds that coat the ear canal to treat infections or inflammation. Here’s how to give them safely:
- Warm the medication in your hands for a minute (don’t overheat).
- Secure your pet comfortably. Lift the ear flap to straighten the canal.
- Clean the ear first only if your vet advised it.
- Add drops: Use the dropper or syringe to apply the prescribed amount into the ear canal. Don’t insert too deep into the ear canal.
- Massage the base of the ear for 20–30 seconds to help spread the medicine.
- Let your pet shake their head, then gently wipe away any excess.
- Repeat for the other ear if needed.
- Praise, treat, and wash your hands.
- Use for the full duration prescribed—don’t stop early, even if the ear looks better.
This compounded formulation combines active ingredients from different drug classes: gentamicin, an aminoglycoside antibiotic; polymixin b, a polymyxin antibiotic; and dexamethasone, a corticosteroid. In compounding practice, clinicians may consider a multi-ingredient preparation like this to address more than one aspect of a patient's physiology at once. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.
This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
At a pharmacological level, gentamicin and polymyxin B manage bacterial populations through different pathways, while dexamethasone modulates inflammation. Commonly observed effects include localized changes such as mild redness or temporary discharge. Because the formulation contains dexamethasone, systemic absorption is possible; your veterinarian will monitor for signs of steroid influence. Ensuring the eardrum is intact is a high-priority clinical safety step. Owners should monitor for behavioral shifts and contact their veterinarian promptly.
Yes. This combination requires a valid prescription from a licensed veterinarian before it can be dispensed. Mixlab verifies all legal authorizations before any medication is prepared or shipped.
Yes. Mixlab specializes in compounding gentamicin, polymyxin B and dexamethasone into customized otic suspensions tailored to the specific needs of your pet’s ears.
Veterinarians may consider combining these ingredients so the preparation can act through more than one mechanism at once — here, it brings together antibacterial and anti-inflammatory actions in one preparation. Your veterinarian determines whether this multi-targeted approach is appropriate for your pet.
You should monitor for observational signs like decreased discharge and improved comfort. If you notice your pet holding their head tilted or appearing dizzy, contact your veterinarian immediately.
Your veterinarian will determine the necessary duration of the management approach. They will provide a specific monitoring schedule to ensure the steroid component remains appropriate for your pet.
