FLUOXetine/PrednisoLONE Transdermal Pen (3mL)
FLUOXetine/PrednisoLONE is a compounded formulation containing FLUOXetine, PrednisoLONE, prepared by Mixlab for veterinary use. Available by prescription.
A transdermal pen is a simple way to give your pet medicine through their skin—usually used for cats by applying gel to the inside of their ear.
Step-by-Step:
- Get the pen ready – Twist the pen to dispense a small amount of gel. If it’s your first time, you will need to “prime” it first (the gel should be flush with the edge of the tip)
- Wear gloves – Always use a disposable glove or finger cot so the medication doesn’t absorb into your skin.
- Twist to dose – Follow the pen’s directions (like two full twists) to get the right amount of gel out. Always click in a clockwise direction, clicking counter-clockwise will stop you
- Pick the spot – Apply to a hairless area, usually the inside of your cat’s ear. Make sure the area is clean and dry.
- Apply the gel – Dab the gel directly with the pen or use your gloved finger to rub it in gently. Avoid the ear canal.
- Let it dry – It usually dries in a minute or two. Try to keep your pet from rubbing it off.
- Recap the pen – This keeps the medication fresh.
- Wash your hands – Even if you wore gloves, wash thoroughly after.
- Reward your pet – A treat helps make it a stress-free routine!
- Store properly – Keep at room temp, away from sunlight. Track doses so you know when it’s time to refill.
Important: Only apply where your vet has directed—usually hairless areas. Never apply over fur or broken skin. Keep other pets from licking the area until it’s dry.
This compounded formulation combines fluoxetine, a selective serotonin reuptake inhibitor (SSRI), with prednisolone, a corticosteroid — two different drug classes. In compounding practice, clinicians may consider a combination like this for a multi-targeted approach. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.
This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
Commonly observed effects include behavioral shifts such as increased thirst and urination (polyuria/polydipsia) and localized digestive changes like a temporary increase in appetite. Because the formulation contains prednisolone, your veterinarian will monitor for observational signs of steroid influence, especially with long-term use. The fluoxetine component manages serotonin concentrations, which can take several weeks to show behavioral shifts. Owners should monitor for significant behavioral changes and contact their veterinarian promptly with concerns.
Yes. This combination requires a valid prescription from a licensed veterinarian before it can be dispensed. Mixlab verifies all professional authorizations before preparing any medication.
Yes. Mixlab specializes in compounding fluoxetine and prednisolone into customized strengths and flavored oral formats, such as flavored liquids or treats, to suit your pet's needs. The decision rests with your prescribing veterinarian.
Veterinarians discuss this combination for pets whose inflammatory or skin challenges may be exacerbated by anxiety or compulsive licking. This dual approach provide a method for managing both the physical and behavioral components.
Both corticosteroids and SSRIs are typically tapered off gradually under professional guidance. Your veterinarian is the right person to provide a proper schedule to manage the risk of withdrawal-like signs or adrenal insufficiency.
Common observational signs include your pet seeking more water or needing more frequent outdoor breaks. If you notice unusual weakness or extreme behavioral shifts, contact your veterinarian for a clinical review.
