Diclofenac Sodium/DMSO Cream
Diclofenac Sodium/DMSO is a compounded formulation containing Diclofenac Sodium, DMSO, prepared by Mixlab for veterinary use. Available by prescription.
How to Apply Topical Cream to Your Pet
Topical creams are smooth, lotion-like medications applied to your pet’s skin to treat infections, wounds, or deliver medicine. Here’s a simple step-by-step guide:
- Prep Yourself: Wash your hands first. Use gloves if advised by your vet.
- Prep the Area: Clean the affected area gently with warm water and pat dry. If needed, part or trim fur to reach the skin (only if your vet recommends).
- Apply the Cream: Use the prescribed amount (usually pea-sized). Apply directly to the skin.
- Spread It Gently: Rub the cream in softly to create a thin, even layer.
- Prevent Licking: Distract your pet or use a cone to stop licking until the cream absorbs.
- Clean Up: Wash your hands (and discard gloves, if used).
- Follow-Up: Reward your pet! Monitor the area and contact your vet if irritation appears.
This compounded formulation combines diclofenac, a non-steroidal anti-inflammatory drug (NSAID), with dmso, a solvent and penetration enhancer — two different drug classes. In compounding practice, clinicians may consider a combination like this for a multi-targeted approach. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.
At a pharmacological level, the components of this formulation act through distinct yet synergistic mechanisms. Diclofenac sodium is an NSAID that inhibits the cyclooxygenase (COX) enzymes, which are essential for the biosynthesis of pro-inflammatory prostaglandins. Dimethyl sulfoxide (DMSO) serves as a specialized vehicle; its unique chemical properties allow it to penetrate biological membranes rapidly, facilitating the movement of the diclofenac sodium into deeper subcutaneous tissues and joint spaces. DMSO is also studied for its own mild osmotic properties and free-radical scavenging activity, which may support the management of localized edema. Your veterinarian will determine the appropriate application based on your horse's diagnostic profile and the specific joints requiring support.
This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
Commonly observed effects of diclofenac sodium/DMSO application include localized skin irritation, such as redness, flaking or mild itching at the site of administration. Because the formulation contains DMSO, owners may observe a characteristic garlic-like odor on the horse’s skin or breath shortly after use. It is critical that the skin at the application site is clean and free of other topical chemicals, as DMSO can facilitate the absorption of environmental contaminants into the bloodstream. To prevent accidental absorption, the person applying the medication should always wear protective gloves. If you observe significant skin blistering, persistent heat in the limb or signs of physical distress, contact your veterinarian promptly.This medication is typically used with extra caution or avoided in horses with known hypersensitivity to NSAIDs or those with pre-existing kidney health concerns, as some systemic absorption does occur. It is also carefully evaluated in breeding, pregnant or lactating mares. Before starting a protocol, ensure your veterinarian has a complete history of all other prescriptions and supplements your horse is receiving. Your veterinarian is the right person to design a comprehensive management plan and provide guidance on the necessary duration of use to ensure the approach remains suitable for your horse's health status. Always consult your veterinarian about the appropriate duration of use and whether your horse's competitive status requires a withdrawal period. Diclofenac (an NSAID) is subject to detection in equine medication-testing programs and specific withdrawal times vary by jurisdiction and governing body.
Yes. Both diclofenac sodium and DMSO are regulated substances in this context and require a valid prescription from a licensed veterinarian. Mixlab verifies all authorizations before any compounded medication is prepared or shipped to your stable.
Yes. Mixlab specializes in compounding these ingredients into customized topical formats—such as gels or liquids—when a veterinarian determines that a specific concentration or preparation better suits an individual patient’s needs. The decision between a commercial and compounded product rests with the prescribing veterinarian.
Veterinarians emphasize the use of gloves because DMSO is a powerful solvent that carries medications and other substances directly through the skin. Wearing gloves may be considered in cases where the concern involves the person administering the medication from accidentally absorbing the diclofenac or any other chemicals present on their hands.
No, diclofenac sodium/DMSO should generally not be applied to broken skin or open wounds. Your veterinarian will provide specific instructions on the appropriate application site to ensure the medication is used safely and for your horse's condition.
