Diclazuril/Vitamin E Succinate Oral Suspension (Anhydrous)
Diclazuril/Vitamin E Succinate is a compounded formulation containing Diclazuril, Vitamin E Succinate, prepared by Mixlab for veterinary use. Available by prescription.
How to Give Anhydrous Oral Suspension
Oral Suspension (Anhydrous) is a liquid medication that does not contain water in its base. This might be an oil-based or other special base to help stabilize the medicine. It will look like a regular liquid medication, but often needs a good shake because the drug can settle. Here's how to give it:
- Shake well each time to mix the medication (5-10 seconds).
- Measure the dose using the syringe/dropper provided or one recommended by your vet. Insert the top of the oral syringe into the bottle adapter. Turn the bottle upside down and pull the plunger until the medicine reaches the volume required
- Hold your pet steady: a towel or helper can assist with squirmy pets.
- Administer the dose slowly into the side of the mouth. Allow small pauses if needed for swallowing.
- Raise the head slightly to help the medication go down and clean any spills with a little water or tissue.
- Praise your pet and offer a treat or water (unless advised against feeding right after).
- Clean the syringe with water immediately after use. Store the bottle as directed, out of sunlight.
- Consistency is key: Shake each time, measure accurately, and contact your vet if any issues arise.
This compounded formulation combines diclazuril, an antiprotozoal, with vitamin e, a fat-soluble antioxidant — two different drug classes. In compounding practice, clinicians may consider a combination like this for a multi-targeted approach. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.
At a pharmacological level, diclazuril acts as an antiprotozoal agent that disrupts the intracellular stages of parasite development by acting on the apicoplast and mitochondria. This interference inhibits the replication and survival of the protozoal organism within the host's central nervous system. Vitamin E succinate functions as a highly bioavailable, fat-soluble antioxidant. It acts at a cellular level to support the protection of neurological tissues from oxidative stress and free-radical damage, which are frequently observed in the context of inflammatory conditions within the spinal cord or brain. Your veterinarian will determine if this combination is appropriate based on your horse's weight, neurological status and diagnostic findings.
This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
Commonly observed effects of diclazuril/vitamin E succinate administration include mild gastrointestinal changes such as loose stools, flatulence or a temporary decrease in appetite. Because neurological conditions can be sensitive to physiological shifts, your veterinarian will monitor for any changes in coordination, alertness or gait during the course of the prescription. In some cases, localized skin irritation or changes in coat quality have been noted. If you observe significant stumbling, persistent diarrhea or signs of physical distress, contact your veterinarian promptly to share these observations.
This medication is typically used with caution in pregnant or lactating mares, as the safety profile for developing foals has not been extensively characterized for this specific combination. It is essential to provide your veterinarian with a complete history of all other supplements and medications your horse is receiving, as the metabolic processing of antioxidants can be influenced by concurrent therapies. Your veterinarian is the best resource for designing a comprehensive approach to patient monitoring and support during the administration period. Always follow the professional guidance provided regarding the duration of use and the timing of any necessary follow-up examinations.
Yes. Diclazuril/vitamin E succinate is a prescription medication and can only be dispensed by a licensed pharmacy like Mixlab upon receipt of a valid authorization from a licensed veterinarian. Mixlab verifies all authorizations before any medication is prepared or sent to your home or stable.
Yes. Since this specific combination is typically available as a compounded preparation, Mixlab can provide it in formats—such as flavored oral pastes or powders—that facilitate easier administration for your horse. Your veterinarian will determine the most appropriate compounded strength and format based on your animal's individual requirements.
Veterinarians may consider combining these ingredients so the preparation can act through more than one mechanism at once — here, it focuses on antiprotozoal action. Your veterinarian determines whether this multi-targeted approach is appropriate for your pet.
Commonly observed effects include mild gastrointestinal upset or changes in appetite. However, because the medication is used in horses with neurological concerns, you should report any changes in gait, coordination or energy levels to your veterinarian immediately to ensure the management plan remains appropriate.
