Credelio Quattro Chewable Tablet
Credelio Quattro is a monthly chewable medication for dogs that prevents heartworm disease, treats and controls fleas, ticks, and multiple types of intestinal worms — offering broad protection against common and potentially serious parasites.
Lotilaner, Moxidectin, Praziquantel, and Pyrantel
Credelio® Quattro is a commercial brand of a multi-agent parasite preventative utilized in veterinary medicine for comprehensive internal and external parasite management. This prescription medication is formulated for use in dogs, frequently considered by veterinarians for the management of fleas, ticks, heartworm disease and common intestinal parasites. At a pharmacological level, Credelio® Quattro provides a combination of lotilaner, moxidectin and pyrantel pamoate. Lotilaner manages fleas and ticks by inhibiting GABA-gated chloride channels, moxidectin manages heartworm larvae and certain mites by influencing glutamate-gated chloride channels and pyrantel acts as a neuromuscular blocker in intestinal worms. This multi-layered approach provides a method for managing a wide spectrum of parasite risks in a single monthly dose. Your veterinarian will determine the appropriateness of Credelio® Quattro based on your dog's weight, age and local heartworm prevalence.
The actions described here reflect the product's FDA-approved labeling; your veterinarian determines the appropriate use for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring.
Commonly observed effects following the administration of Credelio® Quattro include localized digestive changes such as vomiting, diarrhea or a decrease in appetite. Some dogs may exhibit behavioral shifts including lethargy or temporary changes in energy. Because lotilaner belongs to the isoxazoline class, your veterinarian will monitor for potential neurological effects, especially in dogs with a history of seizures. Owners should monitor their pet for any unusual signs of tremors, loss of coordination or breathing changes and contact their veterinarian promptly with any concerns. This medication is typically used with extra caution in dogs with a history of neurological disorders. Before administration, your veterinarian will perform a heartworm test to ensure the pet is negative, as moxidectin is intended for prevention. Significant interactions can occur if this combination is administered concurrently with other parasite preventatives. Your veterinarian is the right person to provide guidance on the necessary frequency of use and the proper monitoring schedule to ensure the management approach remains suitable for your pet's health.
Yes. Credelio Quattro is a prescription medication and can only be dispensed by a licensed pharmacy upon receipt of a valid authorization from a licensed veterinarian. Mixlab verifies authorization before any medication is shipped to your home.
Credelio Quattro is a proprietary commercial combination product. While Mixlab specializes in compounding many customized medications, this specific multi-agent preventative is typically dispensed in its original commercial format. Your veterinarian can discuss other options if needed.
Veterinarians discuss Credelio Quattro because it provides a method for managing fleas, ticks, heartworm disease, roundworms and hookworms. It provides a comprehensive management approach for both external and internal parasites in one monthly dose.
Yes. Veterinarians require a negative heartworm test before beginning any preventative containing moxidectin. This is a safety step to ensure the management approach is appropriate for your dog's current health status.
