Clopidogrel/Enalapril Oral Suspension (Anhydrous)
Clopidogrel/Enalapril is a compounded formulation containing Clopidogrel, Enalapril, prepared by Mixlab for veterinary use. Available by prescription.
How to Give Anhydrous Oral Suspension
Oral Suspension (Anhydrous) is a liquid medication that does not contain water in its base. This might be an oil-based or other special base to help stabilize the medicine. It will look like a regular liquid medication, but often needs a good shake because the drug can settle. Here's how to give it:
- Shake well each time to mix the medication (5-10 seconds).
- Measure the dose using the syringe/dropper provided or one recommended by your vet. Insert the top of the oral syringe into the bottle adapter. Turn the bottle upside down and pull the plunger until the medicine reaches the volume required
- Hold your pet steady: a towel or helper can assist with squirmy pets.
- Administer the dose slowly into the side of the mouth. Allow small pauses if needed for swallowing.
- Raise the head slightly to help the medication go down and clean any spills with a little water or tissue.
- Praise your pet and offer a treat or water (unless advised against feeding right after).
- Clean the syringe with water immediately after use. Store the bottle as directed, out of sunlight.
- Consistency is key: Shake each time, measure accurately, and contact your vet if any issues arise.
This compounded formulation combines clopidogrel, an antiplatelet agent, with enalapril, an ACE inhibitor — two different drug classes. In compounding practice, clinicians may consider a combination like this for a multi-targeted approach. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.
This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
Commonly observed effects following the administration of this combination include localized digestive changes such as vomiting or a temporary decrease in appetite. Because it influences both blood pressure and platelet function, owners should watch for observational signs of unusual weakness, fainting episodes or unexpected bruising and bleeding. Some animals may exhibit behavioral shifts including lethargy. Owners should contact their veterinarian promptly if any signs of prolonged bleeding or significant changes in energy levels occur. This medication is typically used with extra caution or avoided in patients with known severe renal impairment, as ACE inhibitors can influence kidney function. It is also carefully evaluated in pets presented with active pathological bleeding or those receiving other cardiovascular medications. Significant interactions can occur if this combination is administered concurrently with NSAIDs, specific diuretics or other antiplatelet agents. Before starting a protocol, ensure your veterinarian has a complete history of all other prescriptions your pet is receiving. Your veterinarian is the right person to provide guidance on the necessary duration of use and the most commonly considered monitoring schedule to ensure the management approach remains suitable for your pet's cardiac profile.
Yes. This combination contains prescription medications and can only be dispensed by a licensed pharmacy upon receipt of a valid authorization from a licensed veterinarian. Mixlab ensures all prescription requirements are met before any medication is prepared or shipped to your home.
Yes. Because this specific dual-agent combination is not available as a single commercial product, Mixlab specializes in compounding it into customized strengths and flavored dosage forms—such as flavored oral liquids or capsules—to suit the specific needs of dogs and cats. The decision rests with the prescribing veterinarian.
Veterinarians discuss this combination for pets with heart disease to manage two different risks at once: clopidogrel manages the stickiness of platelets to help reduce clots, while enalapril manages the workload of the heart by relaxing blood vessels. This provides a method for managing complex cardiovascular needs in one dose.
Your veterinarian will periodically monitor your pet's blood pressure and kidney function through diagnostic testing. They will also provide guidance on watching for signs of unusual bleeding or changes in your pet's activity levels during the management course.
