CloMIPRAMINE HCl Transdermal Pen (1.5mL)
CloMIPRAMINE HCl is a compounded formulation containing CloMIPRAMINE HCl, prepared by Mixlab for veterinary use. Available by prescription.
A transdermal pen is a simple way to give your pet medicine through their skin—usually used for cats by applying gel to the inside of their ear.
Step-by-Step:
- Get the pen ready – Twist the pen to dispense a small amount of gel. If it’s your first time, you will need to “prime” it first (the gel should be flush with the edge of the tip)
- Wear gloves – Always use a disposable glove or finger cot so the medication doesn’t absorb into your skin.
- Twist to dose – Follow the pen’s directions (like two full twists) to get the right amount of gel out. Always click in a clockwise direction, clicking counter-clockwise will stop you
- Pick the spot – Apply to a hairless area, usually the inside of your cat’s ear. Make sure the area is clean and dry.
- Apply the gel – Dab the gel directly with the pen or use your gloved finger to rub it in gently. Avoid the ear canal.
- Let it dry – It usually dries in a minute or two. Try to keep your pet from rubbing it off.
- Recap the pen – This keeps the medication fresh.
- Wash your hands – Even if you wore gloves, wash thoroughly after.
- Reward your pet – A treat helps make it a stress-free routine!
- Store properly – Keep at room temp, away from sunlight. Track doses so you know when it’s time to refill.
Important: Only apply where your vet has directed—usually hairless areas. Never apply over fur or broken skin. Keep other pets from licking the area until it’s dry.
The uses and pharmacology described below reflect the FDA-approved labeling for this active ingredient; your veterinarian determines whether and how they apply to your animal's treatment plan.
Clomipramine hydrochloride is a tricyclic antidepressant (TCA) utilized in veterinary medicine for the management of various behavioral challenges. It is a prescription medication available for use in dogs and cats, frequently considered by veterinarians to address multifaceted separation anxiety, obsessive-compulsive behaviors or localized anxiety-related conditions. At a pharmacological level, clomipramine acts as a selective inhibitor of serotonin reuptake, while also influencing the reuptake of norepinephrine. By blocking these reabsorption pathways, the medication increases the concentration of these neurotransmitters in the synaptic cleft. Serotonin and norepinephrine are chemical messengers associated with the regulation of mood, emotional response and reactivity. This increase in neurotransmitter availability provides a mechanism for managing reactive states and facilitating a more receptive environment for behavioral training. Your veterinarian will determine the clinical appropriateness of clomipramine based on your pet’s individual behavioral profile and health history.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
Commonly observed effects following the administration of clomipramine include mild sedation, temporary Coordination shifts or localized digestive changes such as vomiting or a decrease in appetite. Some animals may exhibit behavioral shifts including increased thirst, changes in sleep patterns or unusual restlessness. Because clomipramine has anticholinergic properties, it may influence tear production or heart rate in some patients. Owners should monitor their pet for any unusual behavioral changes or persistent digestive distress and contact their veterinarian promptly with any concerns regarding their pet's response to the medication. This medication is typically used with extra caution or avoided in patients with known cardiovascular disease, glaucoma or a history of seizures. It is also carefully evaluated in male animals used for breeding, as it may influence sperm production. Significant interactions can occur if clomipramine is administered concurrently with MAOIs, tramadol or other serotonergic agents. It is important to never discontinue this medication abruptly; your veterinarian is the right person to provide guidance on the necessary duration of use and the proper tapering schedule to ensure the management approach remains suitable for your pet's individual needs.
Yes. Clomipramine is a prescription medication and can only be dispensed by a licensed pharmacy upon receipt of a valid authorization from a licensed veterinarian. Mixlab ensures all prescription requirements are met before any medication is prepared or shipped to your home.
Yes. While clomipramine is available in commercial tablet formats, Mixlab specializes in compounding the active ingredient into customized strengths and flavored dosage forms—such as flavored oral liquids or smaller capsules—to suit the specific needs of dogs and cats. The decision rests with the prescribing veterinarian.
Veterinarians most commonly discuss clomipramine for separation anxiety, compulsive behaviors and certain anxiety-related conditions in pets. It is typically part of a broader management plan that includes behavioral modification and environmental training.
The duration of use is determined by your veterinarian based on your pet's progress and the specific clinical context. Your veterinarian is the right person to provide guidance on when and how to potentially taper the medication as your pet's behavioral goals are met.
