CloMIPRAMINE HCl Oral Suspension (Anhydrous)
CloMIPRAMINE HCl is a compounded formulation containing CloMIPRAMINE HCl, prepared by Mixlab for veterinary use. Available by prescription.
How to Give Anhydrous Oral Suspension
Oral Suspension (Anhydrous) is a liquid medication that does not contain water in its base. This might be an oil-based or other special base to help stabilize the medicine. It will look like a regular liquid medication, but often needs a good shake because the drug can settle. Here's how to give it:
- Shake well each time to mix the medication (5-10 seconds).
- Measure the dose using the syringe/dropper provided or one recommended by your vet. Insert the top of the oral syringe into the bottle adapter. Turn the bottle upside down and pull the plunger until the medicine reaches the volume required
- Hold your pet steady: a towel or helper can assist with squirmy pets.
- Administer the dose slowly into the side of the mouth. Allow small pauses if needed for swallowing.
- Raise the head slightly to help the medication go down and clean any spills with a little water or tissue.
- Praise your pet and offer a treat or water (unless advised against feeding right after).
- Clean the syringe with water immediately after use. Store the bottle as directed, out of sunlight.
- Consistency is key: Shake each time, measure accurately, and contact your vet if any issues arise.
The uses and pharmacology described below reflect the FDA-approved labeling for this active ingredient; your veterinarian determines whether and how they apply to your animal's treatment plan.
Clomipramine hydrochloride is a tricyclic antidepressant (TCA) utilized in veterinary medicine for the management of various behavioral challenges. It is a prescription medication available for use in dogs and cats, frequently considered by veterinarians to address multifaceted separation anxiety, obsessive-compulsive behaviors or localized anxiety-related conditions. At a pharmacological level, clomipramine acts as a selective inhibitor of serotonin reuptake, while also influencing the reuptake of norepinephrine. By blocking these reabsorption pathways, the medication increases the concentration of these neurotransmitters in the synaptic cleft. Serotonin and norepinephrine are chemical messengers associated with the regulation of mood, emotional response and reactivity. This increase in neurotransmitter availability provides a mechanism for managing reactive states and facilitating a more receptive environment for behavioral training. Your veterinarian will determine the clinical appropriateness of clomipramine based on your pet’s individual behavioral profile and health history.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
Commonly observed effects following the administration of clomipramine include mild sedation, temporary Coordination shifts or localized digestive changes such as vomiting or a decrease in appetite. Some animals may exhibit behavioral shifts including increased thirst, changes in sleep patterns or unusual restlessness. Because clomipramine has anticholinergic properties, it may influence tear production or heart rate in some patients. Owners should monitor their pet for any unusual behavioral changes or persistent digestive distress and contact their veterinarian promptly with any concerns regarding their pet's response to the medication. This medication is typically used with extra caution or avoided in patients with known cardiovascular disease, glaucoma or a history of seizures. It is also carefully evaluated in male animals used for breeding, as it may influence sperm production. Significant interactions can occur if clomipramine is administered concurrently with MAOIs, tramadol or other serotonergic agents. It is important to never discontinue this medication abruptly; your veterinarian is the right person to provide guidance on the necessary duration of use and the proper tapering schedule to ensure the management approach remains suitable for your pet's individual needs.
Yes. Clomipramine is a prescription medication and can only be dispensed by a licensed pharmacy upon receipt of a valid authorization from a licensed veterinarian. Mixlab ensures all prescription requirements are met before any medication is prepared or shipped to your home.
Yes. While clomipramine is available in commercial tablet formats, Mixlab specializes in compounding the active ingredient into customized strengths and flavored dosage forms—such as flavored oral liquids or smaller capsules—to suit the specific needs of dogs and cats. The decision rests with the prescribing veterinarian.
Veterinarians most commonly discuss clomipramine for separation anxiety, compulsive behaviors and certain anxiety-related conditions in pets. It is typically part of a broader management plan that includes behavioral modification and environmental training.
The duration of use is determined by your veterinarian based on your pet's progress and the specific clinical context. Your veterinarian is the right person to provide guidance on when and how to potentially taper the medication as your pet's behavioral goals are met.
