Cisapride Transdermal Pen (6mL)

A transdermal pen is a simple way to give your pet medicine through their skin—usually used for cats by applying gel to the inside of their ear.

Step-by-Step:

1. Get the pen ready – Twist the pen to dispense a small amount of gel. If it’s your first time, you will need to “prime” it first (the gel should be flush with the edge of the tip)
2. Wear gloves – Always use a disposable glove or finger cot so the medication doesn’t absorb into your skin.
3. Twist to dose – Follow the pen’s directions (like two full twists) to get the right amount of gel out. Always click in a clockwise direction, clicking counter-clockwise will stop you
4. Pick the spot – Apply to a hairless area, usually the inside of your cat’s ear. Make sure the area is clean and dry.
5. Apply the gel – Dab the gel directly with the pen or use your gloved finger to rub it in gently. Avoid the ear canal.
6. Let it dry – It usually dries in a minute or two. Try to keep your pet from rubbing it off.
7. Recap the pen – This keeps the medication fresh.
8. Wash your hands – Even if you wore gloves, wash thoroughly after.
9. Reward your pet – A treat helps make it a stress-free routine!
10. Store properly – Keep at room temp, away from sunlight. Track doses so you know when it’s time to refill.

Important: Only apply where your vet has directed—usually hairless areas. Never apply over fur or broken skin. Keep other pets from licking the area until it’s dry.

The uses and pharmacology described below reflect the FDA-approved labeling for this active ingredient; your veterinarian determines whether and how they apply to your animal's treatment plan.

Veterinarians most commonly consider cisapride for feline patients presented with chronic constipation or megacolon. It is also frequently a point of discussion for managing canine patients with esophageal reflux or localized delays in stomach emptying (gastroparesis). By enhancing the tone and coordination of the smooth muscles in the gut, your veterinarian can manage the transition of food and waste through the gastrointestinal system. At a pharmacological level, cisapride acts as a serotonin 5-HT4 receptor agonist and a 5-HT3 receptor antagonist. the stimulation of 5-HT4 receptors on the enteric neurons triggers the release of acetylcholine at the myenteric plexus. This increase in acetylcholine promotes the contraction of smooth muscle across the entire length of the digestive tract, including the esophagus, stomach and intestines. cisapride provides a advantage by influencing motility in the distal portions of the gut, such as the colon. Your veterinarian will determine the clinical appropriateness of cisapride based on diagnostic findings like radiographs or ultrasound.

Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.

Commonly observed effects following the administration of cisapride include localized digestive changes such as loose stools, diarrhea or abdominal discomfort. Some pets may exhibit behavioral shifts including lethargy or a decrease in appetite. Owners should monitor their pet for any unusual signs of abdominal pain or significant shifts in bowel habits and contact their veterinarian promptly with any concerns. This medication is typically used with extra caution or avoided in patients presented with a known gastrointestinal obstruction or perforation, as increased motility can be counterproductive in these cases. It is also carefully evaluated in pets with a history of cardiac arrhythmias or hepatic impairment. Significant interactions can occur if cisapride is administered concurrently with certain antifungal medications or macrolide antibiotics, as these combinations can influence the clearance of cisapride from the system. Your veterinarian is the right person to provide guidance on the necessary duration of use and to ensure the administration protocol is appropriately tailored to your pet's health status.