ChloramPHENICOL/Doxycycline (as Hyclate)/KETOconazole clEARmix Lanolin Otic (3mL Syringe)

How to Use clEARmix Lanolin Otic (Ear Medication)

This is a thick ear ointment used to treat ear infections. It comes in a pre-filled syringe with a soft tip, making it easier to apply and designed to stay in your pet’s ear longer.

Step-by-Step: 1. Warm the syringe – If it’s cold, hold it in your hands for a minute to soften the ointment. Do not microwave. 2. Position your pet – Have them sit in a comfy spot. You may need someone to gently help hold them. Lift their ear flap straight up. 3. Clean the ear (if needed) – Only if your vet told you to. Use a vet-approved ear cleaner and cotton ball—never a Q-tip deep in the ear. Let the ear dry. 4. Apply the medication – Remove the cap, then gently insert just the tip of the syringe into the ear opening. Don’t push in deep. 5. Dispense slowly – Press the plunger gently to apply the full dose or the amount your vet prescribed. 6. Massage the ear – Rub the base of the ear for about 30 seconds to help the medication spread. 7. Let them shake – It’s normal! Wipe off any excess with a tissue or cloth. 8. Reward your pet – Give them praise and maybe a treat to make it a positive experience. 9. Store the rest – If there’s more medication left, recap the syringe and store at room temp. Wash your hands after use.

This compounded formulation combines active ingredients from different drug classes: chloramphenicol, an antibiotic; doxycycline, a tetracycline antibiotic; and ketoconazole, an azole antifungal. In compounding practice, clinicians may consider a multi-ingredient preparation like this to address more than one aspect of a patient's physiology at once. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.

This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.

Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.

Commonly observed effects following the administration of this combination include localized digestive changes such as vomiting, diarrhea or a temporary decrease in appetite. A high-priority clinical consideration for chloramphenicol is its influence on bone marrow function; your veterinarian will direct periodic blood work to monitor for reversible bone marrow suppression. Additionally, ketoconazole may influence hepatic enzyme levels, requiring regular monitoring of liver health. Owners should watch for behavioral shifts including lethargy or unusual weakness and contact their veterinarian promptly with any concerns.

This medication is typically used with extra caution or avoided in patients with known severe hepatic or renal impairment or pre-existing blood disorders. Doxycycline hyclate is associated with localized irritation if a tablet becomes lodged in the esophagus, so your veterinarian may recommend following administration with a small amount of water. Because both chloramphenicol and ketoconazole can interfere with the metabolism of other prescriptions, a complete history of all other medications your pet is receiving is essential. Furthermore, humans handling chloramphenicol should follow specific safety precautions, such as wearing gloves, as directed by their veterinarian. Your veterinarian is the right person to provide guidance on the necessary monitoring frequency to ensure the management approach remains suitable for your pet's recovery.