
Calmera (Clomipramine HCl) is an FDA-approved commercial tablet, dispensed by Mixlab for veterinary use in dogs. Available by prescription.
Clomipramine hydrochloride is a tricyclic antidepressant that increases serotonin availability in the brain. It is FDA-approved, in conjunction with behavior modification, for the treatment of separation anxiety in dogs. Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing, or monitoring.
This medication works best alongside a structured behavior modification plan — ask your veterinarian or a veterinary behaviorist for guidance. Commonly reported effects include vomiting, lethargy, and decreased appetite. Do not stop this medication abruptly; your veterinarian will advise on tapering if treatment is discontinued. Avoid use in dogs with a history of seizures, heart disease, or glaucoma, and avoid combining with other serotonergic medications unless directed by your veterinarian.
Yes. Calmera is available only by prescription from a licensed veterinarian.
Yes. Calmera (clomipramine HCl) is an FDA-approved commercial product, dispensed by Mixlab under a licensed veterinarian's prescription.
Calmera is FDA-approved, alongside behavior modification, for the treatment of separation anxiety in dogs.
Contact your veterinarian if you notice excessive sedation, unsteadiness, or a change in appetite or energy level.




