Benazepril HCl Transdermal Pen (3mL)

A transdermal pen is a simple way to give your pet medicine through their skin—usually used for cats by applying gel to the inside of their ear.

Step-by-Step:

1. Get the pen ready – Twist the pen to dispense a small amount of gel. If it’s your first time, you will need to “prime” it first (the gel should be flush with the edge of the tip)
2. Wear gloves – Always use a disposable glove or finger cot so the medication doesn’t absorb into your skin.
3. Twist to dose – Follow the pen’s directions (like two full twists) to get the right amount of gel out. Always click in a clockwise direction, clicking counter-clockwise will stop you
4. Pick the spot – Apply to a hairless area, usually the inside of your cat’s ear. Make sure the area is clean and dry.
5. Apply the gel – Dab the gel directly with the pen or use your gloved finger to rub it in gently. Avoid the ear canal.
6. Let it dry – It usually dries in a minute or two. Try to keep your pet from rubbing it off.
7. Recap the pen – This keeps the medication fresh.
8. Wash your hands – Even if you wore gloves, wash thoroughly after.
9. Reward your pet – A treat helps make it a stress-free routine!
10. Store properly – Keep at room temp, away from sunlight. Track doses so you know when it’s time to refill.

Important: Only apply where your vet has directed—usually hairless areas. Never apply over fur or broken skin. Keep other pets from licking the area until it’s dry.

The uses and pharmacology described below reflect the FDA-approved labeling for this active ingredient; your veterinarian determines whether and how they apply to your animal's treatment plan.

Veterinarians most commonly consider benazepril hydrochloride in the context of congestive heart failure, particularly secondary to degenerative mitral valve disease or dilated cardiomyopathy. It is also frequently a point of discussion for kidney health protocols in feline patients presented with chronic renal insufficiency, where managing the pressure within the functional units of the kidney is a clinical priority. By modulating the biochemical pathways that regulate blood vessel diameter, your veterinarian can manage the mechanical workload placed on the heart and the filtration pressure within the renal system.

At a pharmacological level, benazepril is a prodrug that is hydrolyzed in the body to its active metabolite, benazeprilat. Benazeprilat acts by inhibiting the angiotensin-converting enzyme, which help address the conversion of angiotensin I to angiotensin II. Because angiotensin II is a potent vasoconstrictor and a primary stimulator of aldosterone secretion, its reduction leads to systemic vasodilation and decreased sodium and water retention. This reduction in "afterload" and "preload" helps the heart pump blood more efficiently. In the kidneys, this mechanism specifically manages the efferent arteriolar resistance, which supports the preservation of renal architecture over time. Your veterinarian will determine the clinical appropriateness of this medication based on blood pressure readings and diagnostic testing.

Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.

Commonly observed effects following the administration of benazepril hydrochloride include localized digestive changes such as vomiting, loose stools or a decrease in appetite. Some pets may exhibit behavioral shifts including lethargy or a noticeable decrease in activity level. Because this medication influences systemic blood pressure, your veterinarian will monitor for signs of hypotension (low blood pressure), which can manifest as significant weakness or disorientation. Owners should watch for any persistent coughing or sudden shifts in water consumption and contact their veterinarian promptly if these occur.

This medication is typically used with extra caution or avoided in patients with known severe sodium depletion, dehydration or pre-existing low blood pressure. It is also carefully evaluated in pregnant or lactating animals, as ACE inhibitors are associated with specific developmental considerations in fetal health. Before starting a protocol, ensure your veterinarian has a complete history of all other prescriptions and supplements your pet is receiving, as significant interactions can occur with non-steroidal anti-inflammatory medications (NSAIDs) or certain diuretics. Your veterinarian is the right person to provide guidance on the necessary monitoring frequency for kidney values and blood pressure to ensure the management approach remains suitable for your pet's individual health status.