Amlodipine/PrednisoLONE Transdermal Pen (9mL)
Amlodipine/PrednisoLONE is a compounded formulation containing Amlodipine, PrednisoLONE, prepared by Mixlab for veterinary use. Available by prescription.
A transdermal pen is a simple way to give your pet medicine through their skin—usually used for cats by applying gel to the inside of their ear.
Step-by-Step:
- Get the pen ready – Twist the pen to dispense a small amount of gel. If it’s your first time, you will need to “prime” it first (the gel should be flush with the edge of the tip)
- Wear gloves – Always use a disposable glove or finger cot so the medication doesn’t absorb into your skin.
- Twist to dose – Follow the pen’s directions (like two full twists) to get the right amount of gel out. Always click in a clockwise direction, clicking counter-clockwise will stop you
- Pick the spot – Apply to a hairless area, usually the inside of your cat’s ear. Make sure the area is clean and dry.
- Apply the gel – Dab the gel directly with the pen or use your gloved finger to rub it in gently. Avoid the ear canal.
- Let it dry – It usually dries in a minute or two. Try to keep your pet from rubbing it off.
- Recap the pen – This keeps the medication fresh.
- Wash your hands – Even if you wore gloves, wash thoroughly after.
- Reward your pet – A treat helps make it a stress-free routine!
- Store properly – Keep at room temp, away from sunlight. Track doses so you know when it’s time to refill.
Important: Only apply where your vet has directed—usually hairless areas. Never apply over fur or broken skin. Keep other pets from licking the area until it’s dry.
This compounded formulation combines amlodipine, a calcium channel blocker, with prednisolone, a corticosteroid — two different drug classes. In compounding practice, clinicians may consider a combination like this for a multi-targeted approach. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.
At a pharmacological level, this medication functions through two distinct pathways. Amlodipine acts by inhibiting the movement of calcium ions into vascular smooth muscle cells, which results in the relaxation of the peripheral arteries and a decrease in systemic vascular resistance. Prednisolone is a glucocorticoid that binds to intracellular receptors to modulate gene expression, stopping the production of various inflammatory mediators and stabilizing cellular membranes. Together, these active ingredients address both the mechanical resistance within the circulatory system and the biochemical signals of inflammation. Your veterinarian will determine the clinical appropriateness of this combination based on your pet’s diagnostic testing results and overall metabolic status.
This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
Commonly observed effects of amlodipine/prednisolone administration include increased thirst (polydipsia), increased frequency of urination (polyuria) and a localized increase in appetite. Because this medication influences systemic circulation and immune function, some pets may experience lethargy or localized digestive changes such as vomiting or loose stools. Your veterinarian will monitor for shifts in blood pressure and renal parameters through periodic blood work to ensure the medication remains suitable for your pet’s individual health status. Owners should watch for signs of persistent weakness, significant behavioral changes or unusual lethargy and contact their veterinarian promptly if these occur.
This medication is typically used with extra caution or avoided in patients with known systemic fungal infections, severe dehydration or pre-existing low blood pressure. Due to the steroid component, it is also carefully evaluated in patients with diabetes mellitus or those requiring significant wound healing. Before starting a protocol, ensure your veterinarian has a complete history of all other prescriptions and supplements your pet is receiving, as significant interactions can occur with non-steroidal anti-inflammatory medications (NSAIDs), certain diuretics and other heart medications. Your veterinarian is the right person to provide guidance on the necessary duration of use and the most commonly considered monitoring plan to ensure the management approach remains suitable for your pet's needs.
Yes. Amlodipine/prednisolone is a combination prescription medication and can only be dispensed by a licensed pharmacy upon receipt of a valid authorization from a licensed veterinarian. Mixlab verifies all authorizations before any medication is prepared or shipped to your home.
Yes. While the individual components are available commercially, Mixlab specializes in compounding amlodipine/prednisolone into specialized combination strengths or alternative flavored dosage forms—such as oral liquids or chewable may be considered in cases of—if your veterinarian determines a customized preparation better suits your pet’s needs. The decision between a commercial and compounded product rests with the prescribing veterinarian.
Veterinarians may consider combining these ingredients so the preparation can act through more than one mechanism at once — here, it focuses on anti-inflammatory action. Your veterinarian determines whether this multi-targeted approach is appropriate for your pet.
You will likely observe that your pet drinks more water and urinates more frequently due to the prednisolone component. However, any signs of significant weakness, disorientation or persistent digestive upset should be reported to your veterinarian immediately so they can evaluate your pet's blood pressure and metabolic balance.
