Toltrazuril/Diclazuril Paste
Toltrazuril/Diclazuril is a compounded formulation containing Toltrazuril, Diclazuril, prepared by Mixlab for veterinary use. Available by prescription.
Paste medications are thick and sticky, usually given by mouth using a syringe or tube. They’re often used for dewormers or other oral meds in horses, dogs, and cats. The key is to aim for the back of the mouth so your pet swallows the paste instead of spitting it out.
For Horses:
- Set the dose on the syringe if it has markings (usually based on weight).
- Stand beside your horse, not in front, and have someone hold them if possible.
- Gently insert your thumb into the side of the horse’s mouth (between the teeth) to open it.
- Insert the syringe into that gap and squirt the paste toward the back of the tongue.
- Lift the horse’s head slightly and encourage swallowing by stroking the throat or gently blowing on the nostrils.
- Watch for licking or chewing—that means they swallowed. If paste spills out, check how much was lost and contact your vet if unsure.
- You can offer a little water afterward and reward them with a treat like a carrot if allowed.
For Dogs & Cats:
- Gently open your pet’s mouth or slip the syringe into the side of it.
- Aim toward the back of the tongue and squirt the paste in.
- Hold the mouth closed briefly, and rub the throat or blow gently on the nose to encourage swallowing.
- Give praise or a treat afterward to make it a positive experience.
Aftercare:
- Wipe your pet’s mouth if needed.
- Clean or recap the syringe as instructed.
- Store the tube according to label directions.
Tip: Paste can feel weird to pets at first. For horses, try giving applesauce by syringe ahead of time so they get used to the sensation.
This compounded formulation combines toltrazuril, an antiprotozoal, with diclazuril, an antiprotozoal — two different drug classes. In compounding practice, clinicians may consider a combination like this for a multi-targeted approach. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.
At a pharmacological level, both toltrazuril and diclazuril act as coccidiocides by interfering with the nuclear division and metabolic organelles of the parasite. Specifically, these medications target the apicoplast and the respiratory chain enzymes, disrupting the parasite’s ability to produce energy and replicate. Toltrazuril is studied for its activity across all intracellular developmental stages of coccidia, including schizonts and gamonts. Diclazuril is characterized by its high potency and its ability to achieve therapeutic concentrations in specific tissues. Your veterinarian will determine the appropriate application of this combination based on the species, weight and the specific results of diagnostic testing.
This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
Commonly observed effects of toltrazuril/diclazuril administration include mild gastrointestinal changes such as loose manure or a temporary decrease in appetite. Some animals may exhibit transient lethargy or localized skin irritation shortly after the medication is started. Because these agents target internal parasites, owners may observe a temporary exacerbation of clinical signs as the body responds to the targeted life stages. If you observe significant stumbling, persistent vomiting or signs of physical distress, contact your veterinarian promptly.This medication is typically used with extra caution or avoided in debilitated animals or those with significant liver or kidney impairment, as these organs are involved in the metabolic processing of the compounds. It is also carefully evaluated in breeding, pregnant or lactating animals, as the safety profile for developing offspring is a point of professional consideration. Before starting a protocol involving toltrazuril/diclazuril, ensure your veterinarian has a complete history of all other prescriptions and supplements your pet is receiving. Your veterinarian is the right person to design a comprehensive monitoring plan and provide guidance on environmental hygiene to ensure the management approach remains suitable for your pet’s individual health status.
Yes. Toltrazuril/diclazuril is a combination of prescription medications and can only be dispensed by a licensed pharmacy upon receipt of a valid authorization from a licensed veterinarian. Mixlab verifies all authorizations before any medication is prepared or shipped.
Yes. Since this specific combination is not available as a single commercial product, Mixlab’s compounding team can prepare it in specialized concentrations or flavored dosage forms—such as oral pastes or suspensions—when a veterinarian determines that a customized preparation better suits an individual patient’s needs. The decision between a commercial and compounded product rests with the prescribing veterinarian.
Veterinarians discuss the combination of toltrazuril and diclazuril to provide a multifaceted approach to protozoal management. While they belong to the same class, the combination is sometimes considered to leverage their collective activity across various stages of the parasite life cycle and to ensure therapeutic levels are achieved in the target tissues.
Owners should monitor for mild digestive shifts, such as changes in manure consistency and observe the animal’s general energy levels and coordination. It is important to report any significant behavioral changes or signs of physical discomfort to your veterinarian to ensure the management plan progresses safely.
