SulfaDIAZINE/Trimethoprim Paste
SulfaDIAZINE/Trimethoprim is a compounded formulation containing SulfaDIAZINE, Trimethoprim, prepared by Mixlab for veterinary use. Available by prescription.
Paste medications are thick and sticky, usually given by mouth using a syringe or tube. They’re often used for dewormers or other oral meds in horses, dogs, and cats. The key is to aim for the back of the mouth so your pet swallows the paste instead of spitting it out.
For Horses:
- Set the dose on the syringe if it has markings (usually based on weight).
- Stand beside your horse, not in front, and have someone hold them if possible.
- Gently insert your thumb into the side of the horse’s mouth (between the teeth) to open it.
- Insert the syringe into that gap and squirt the paste toward the back of the tongue.
- Lift the horse’s head slightly and encourage swallowing by stroking the throat or gently blowing on the nostrils.
- Watch for licking or chewing—that means they swallowed. If paste spills out, check how much was lost and contact your vet if unsure.
- You can offer a little water afterward and reward them with a treat like a carrot if allowed.
For Dogs & Cats:
- Gently open your pet’s mouth or slip the syringe into the side of it.
- Aim toward the back of the tongue and squirt the paste in.
- Hold the mouth closed briefly, and rub the throat or blow gently on the nose to encourage swallowing.
- Give praise or a treat afterward to make it a positive experience.
Aftercare:
- Wipe your pet’s mouth if needed.
- Clean or recap the syringe as instructed.
- Store the tube according to label directions.
Tip: Paste can feel weird to pets at first. For horses, try giving applesauce by syringe ahead of time so they get used to the sensation.
This compounded formulation combines sulfadiazine, a sulfonamide antibacterial, with trimethoprim, an antibacterial (folate-pathway inhibitor) — two different drug classes. In compounding practice, clinicians may consider a combination like this for a multi-targeted approach. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.
This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
At a pharmacological level, it manages bacterial populations by inhibiting two sequential steps in folate synthesis. Commonly observed effects include localized digestive changes such as vomiting or diarrhea. A high-priority clinical consideration for sulfonamides is the risk of dry eye (KCS) or skin reactions; your veterinarian will monitor for observational signs of tear production. Owners should monitor for any unusual discharge or cloudiness in the eye and contact their veterinarian promptly.
Yes. This combination requires a valid prescription from a licensed veterinarian before it can be dispensed. Mixlab verifies all professional authorizations before prepares any medication.
Yes. Mixlab specializes in compounding sulfadiazine and trimethoprim into customized strengths and flavored oral formats, such as flavored oral liquids or treats, to suit your pet’s preferences.
Veterinarians discuss this combination because the two agents work together to block bacterial growth than either could alone. This dual approach offers an approach to managing resistant bacteria.
Your veterinarian will recommend periodic check-ups and may suggest tear tests to monitor eye health. This monitoring ensures the management approach remains safe for your pet's long-term comfort.
Certain breeds, such as Doberman Pinschers, may have a known sensitivity to sulfonamides. Your veterinarian will determine the most suitable protocol based on your pet's specific breed and history.
