Regu-Mate (Altrenogest) Oral Progestin Solution
Regu-Mate (Altrenogest) Oral Progestin is an FDA-approved preparation containing Altrenogest, for veterinary use. Available by prescription.
Veterinarians most commonly consider Regu-Mate when the primary clinical objective is the suppression of estrus (heat) in mares. It is frequently a point of discussion for managing the timing of the breeding cycle, allowing for more predictable reproductive scheduling. Additionally, some veterinarians have considered altrenogest in the context of equine reproductive health for mares with a history of early embryonic loss where maintaining a pregnancy is a clinical priority. By providing a synthetic source of progestational activity, your veterinarian can manage the mare’s hormonal environment during periods of reproductive transition.
At a pharmacological level, altrenogest acts by binding to progesterone receptors, mimicking the effects of natural progesterone produced by the corpus luteum. This mechanism suppresses the release of gonadotropins from the pituitary gland, which is understood to inhibit the maturation of follicles and the behavioral signs associated with estrus. When the medication is discontinued, the suppression is lifted, typically leading to a predictable return to the estrous cycle. Your veterinarian will determine whether Regu-Mate is appropriate based on the mare’s reproductive history, physical examination and specific breeding objectives.
The actions described here reflect the product's FDA-approved labeling; your veterinarian determines the appropriate use for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring.
Commonly observed effects of Regu-Mate administration in mares are infrequent but may include localized skin irritation or slight changes in appetite. A critical safety consideration for this medication involves human handling rather than the animal itself. Altrenogest can be absorbed through the skin and is associated with significant physiological shifts in humans, particularly regarding the reproductive cycle and pregnancy. Because of this, anyone handling the medication must wear non-porous protective gloves (such as chemical-resistant nitrile or neoprene) and avoid direct skin contact. If you observe any unexpected behavioral changes in your mare or if accidental human exposure occurs, contact your veterinarian or a medical professional promptly.This medication is typically used with caution or avoided in mares with known uterine infections, as progestins can influence the local immune environment within the uterus. It is strictly intended for use in horses and is not discussed for use in other species without specific professional guidance. Before starting a protocol, ensure your veterinarian has a complete history of all other prescriptions and supplements your mare is receiving. Your veterinarian is the right person to design a comprehensive management approach and provide specific guidance on the timing of administration to ensure the reproductive objectives are met safely and.
Yes. Regu-Mate is a prescription medication and can only be dispensed by a licensed pharmacy upon receipt of a valid authorization from a licensed veterinarian. Mixlab verifies all authorizations before any medication is prepared or shipped to your stable.
Yes. While Regu-Mate is available as a commercial oil-based solution, Mixlab can compound the active ingredient, altrenogest, into specialized concentrations or alternative flavored dosage forms when a veterinarian determines that a customized preparation better suits an individual mare's needs. The decision between a commercial and compounded product rests with the prescribing veterinarian.
Veterinarians emphasize the use of gloves because altrenogest is easily absorbed through human skin and can disrupt the human reproductive system. Proper protective equipment is essential to prevent accidental exposure for anyone involved in administering the medication to the mare.
Altrenogest is a synthetic version of progesterone, the hormone responsible for maintaining pregnancy and preventing estrus behaviors. Veterinarians discuss its use as a progestin to help stabilize the hormonal environment, either to keep a mare out of heat or to support the early stages of a pregnancy.
