Polymyxin B/KETOconazole/Betamethasone clEARmix Lanolin Otic (3mL Syringe)
Polymyxin B/KETOconazole/Betamethasone is a compounded formulation containing Polymyxin B, KETOconazole, Betamethasone, prepared by Mixlab for veterinary use. Available by prescription.
How to Use clEARmix Lanolin Otic (Ear Medication)
This is a thick ear ointment used to treat ear infections. It comes in a pre-filled syringe with a soft tip, making it easier to apply and designed to stay in your pet’s ear longer.
Step-by-Step: 1. Warm the syringe – If it’s cold, hold it in your hands for a minute to soften the ointment. Do not microwave. 2. Position your pet – Have them sit in a comfy spot. You may need someone to gently help hold them. Lift their ear flap straight up. 3. Clean the ear (if needed) – Only if your vet told you to. Use a vet-approved ear cleaner and cotton ball—never a Q-tip deep in the ear. Let the ear dry. 4. Apply the medication – Remove the cap, then gently insert just the tip of the syringe into the ear opening. Don’t push in deep. 5. Dispense slowly – Press the plunger gently to apply the full dose or the amount your vet prescribed. 6. Massage the ear – Rub the base of the ear for about 30 seconds to help the medication spread. 7. Let them shake – It’s normal! Wipe off any excess with a tissue or cloth. 8. Reward your pet – Give them praise and maybe a treat to make it a positive experience. 9. Store the rest – If there’s more medication left, recap the syringe and store at room temp. Wash your hands after use.
This compounded formulation combines active ingredients from different drug classes: polymyxin B, a polymyxin antibiotic; ketoconazole, an azole antifungal; and betamethasone, a corticosteroid. In compounding practice, clinicians may consider a multi-ingredient preparation like this to address more than one aspect of a patient's physiology at once. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.
This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
At a pharmacological level, polymyxin B is used in the context of managing bacterial membranes and ketoconazole manages fungal membranes, while betamethasone modulates the localized inflammatory response. Commonly observed effects include localized changes such as mild redness or temporary discharge. Ensuring the tympanic membrane is intact is a high-priority clinical safety step before application. Owners should watch for behavioral shifts including a head tilt or loss of balance and contact their veterinarian promptly.
Yes. This combination requires a valid prescription from a licensed veterinarian before it can be dispensed. Mixlab verifies all professional authorizations before preparing any medication.
Yes. Mixlab specializes in compounding polymyxin B, ketoconazole and betamethasone into customized otic suspensions tailored to the specific needs of your pet’s ears.
Veterinarians may consider combining these ingredients so the preparation can act through more than one mechanism at once — here, it brings together antibacterial, antifungal and anti-inflammatory actions in one preparation. Your veterinarian determines whether this multi-targeted approach is appropriate for your pet.
Mild, temporary redness can be a commonly observed effect, but persistent irritation should be reported. Your veterinarian will determine if the management approach remains suitable.
Your veterinarian will typically recommend follow-up cytology to monitor the status of the bacterial and fungal populations. This offers an approach to ensuring the protocol is appropriate.
