Polymyxin B/Dexamethasone clEARmix Thermo Gel Otic (3mL Syringe)
Polymyxin B/Dexamethasone is a compounded formulation containing Polymyxin B, Dexamethasone, prepared by Mixlab for veterinary use. Available by prescription.
How to Use clEARmix Thermo Gel Otic (Ear Medication)
This is a liquid ear medication that turns into a gel once it warms up in your pet’s ear, helping it stay in place and work effectively. It comes in a soft-tipped syringe for easy use.
Step-by-Step:
- Keep it cool – Store in the fridge if instructed. Before using, hold the syringe in your hands for a minute so it’s not too cold, but don’t warm it too much.
- Get your pet ready – Have them sit comfortably and gently lift the ear flap. A second person can help hold them still if needed.
- Clean the ear (if advised) – Use a vet-approved ear cleaner and cotton ball. Wipe out any debris and let the ear dry.
- Apply the medication – Take off the cap. Gently insert just the tip into the ear opening (not deep), and slowly press the plunger to deliver the full dose.
- Massage the ear – Rub the base of the ear for 30 seconds. The liquid will turn into a gel as it warms, and massaging helps it spread inside the ear.
- Let them shake it out – It’s normal! Wipe away any extra gel you see near the ear opening.
- Reward your pet – Offer praise or a treat to keep the experience positive.
- Store and clean up – Recap the syringe and refrigerate if needed. Wash your hands afterward.
This compounded formulation combines polymyxin B, a polymyxin antibiotic, with dexamethasone, a corticosteroid — two different drug classes. In compounding practice, clinicians may consider a combination like this for a multi-targeted approach. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.
This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
At a pharmacological level, polymyxin B is used in the context of managing gram-negative bacterial populations while dexamethasone modulates the inflammatory response. Commonly observed effects include localized changes at the site of application such as mild redness or temporary discharge. Because the formulation contains a corticosteroid, your veterinarian will monitor for observational signs of systemic influence. Ensuring the eardrum is intact is a high-priority clinical consideration before otic use. Owners should monitor for behavioral shifts and contact their veterinarian promptly.
Yes. This combination requires a valid prescription from a licensed veterinarian before it can be dispensed. Mixlab verifies all legal authorizations before any medication is prepared or shipped.
Yes. Mixlab specializes in compounding polymyxin B and dexamethasone into customized sterile eye drops or otic suspensions tailored to the specific needs of your pet.
Veterinarians may consider combining these ingredients so the preparation can act through more than one mechanism at once — here, it brings together antibacterial and anti-inflammatory actions in one preparation. Your veterinarian determines whether this multi-targeted approach is appropriate for your pet.
You should monitor for observational signs like decreased redness and improved comfort. If you notice increased squinting or cloudiness, contact your veterinarian immediately for a clinical review.
Your veterinarian will determine the necessary duration of the management approach. They will provide a specific monitoring schedule to ensure the steroid component remains appropriate for your pet.
