Omeprazole/Sucralfate Powder

Powder medications are meant to be mixed into food or treats, not given on their own (since most pets won’t lick up plain powder). The key is to mix it into something tasty so your pet eats the entire dose.

How to Give It:

1. Measure the dose using the included scoop or follow the instructions. If you’re unsure how much to give, ask your vet or pharmacist.
2. Mix it with a small amount of soft food or treat—like wet food, baby food (meat flavor), peanut butter (xylitol-free), yogurt, or cheese. Use just enough to hide the powder so your pet finishes it all in one go.
3. Stir it well to blend the powder in evenly. Add a splash of water if needed to make it smoother.
4. Offer it when your pet is a little hungry, and watch to make sure they eat the whole thing.
5. If your pet refuses, try something else they love next time. For cats, you can also try smearing the paste on their paw to lick off (only if safe and comfortable).
6. For large animals, mix the powder into a small portion of feed with water or molasses, then follow with the rest of their food once they’ve eaten the medicated part.
7. Store the powder in a cool, dry place with the lid closed tightly.

Never give powder straight into your pet’s mouth—it can be dangerous if inhaled.

This compounded formulation combines omeprazole, a proton pump inhibitor, with sucralfate, a mucosal protectant, drawing on two different drug classes. In compounding practice, clinicians may consider a combination like this to support the gastric environment through more than one mechanism. Your veterinarian determines whether it is appropriate for your animal's species and health status.

At a pharmacological level, omeprazole binds to the hydrogen-potassium ATPase enzyme system within the gastric parietal cells, suppressing the final step of acid secretion. Sucralfate is a complex of aluminum hydroxide and sulfated sucrose; in an acidic environment it forms a viscous paste that binds to the surface of the gastric mucosa, creating a physical barrier over the lining. Because sucralfate requires an acidic environment to activate and omeprazole reduces acidity, your veterinarian will provide specific guidance on the timing of administration.

This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.

Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.

Commonly observed effects of omeprazole/sucralfate are generally mild but may include gastrointestinal changes such as constipation, loose stools or a temporary decrease in appetite. Because sucralfate contains aluminum, it may interfere with the absorption of other oral medications. Your veterinarian will monitor for these interactions and may recommend separating the administration of this combination from other prescriptions by several hours.

This medication is typically used with extra caution in patients with known kidney impairment or those with a history of intestinal motility concerns. In horses, veterinarians monitor for any signs of discomfort or changes in fecal consistency during the administration period. It is essential to provide your veterinarian with a complete history of all other medications and supplements your pet is receiving to ensure the most appropriate management plan. If you observe significant behavioral changes, persistent vomiting or signs of physical discomfort, contact your veterinarian promptly to share these observations. Your veterinarian is the best resource for designing a comprehensive approach to your pet's digestive health.