Omeprazole/Misoprostol Powder

Powder medications are meant to be mixed into food or treats, not given on their own (since most pets won’t lick up plain powder). The key is to mix it into something tasty so your pet eats the entire dose.

How to Give It:

1. Measure the dose using the included scoop or follow the instructions. If you’re unsure how much to give, ask your vet or pharmacist.
2. Mix it with a small amount of soft food or treat—like wet food, baby food (meat flavor), peanut butter (xylitol-free), yogurt, or cheese. Use just enough to hide the powder so your pet finishes it all in one go.
3. Stir it well to blend the powder in evenly. Add a splash of water if needed to make it smoother.
4. Offer it when your pet is a little hungry, and watch to make sure they eat the whole thing.
5. If your pet refuses, try something else they love next time. For cats, you can also try smearing the paste on their paw to lick off (only if safe and comfortable).
6. For large animals, mix the powder into a small portion of feed with water or molasses, then follow with the rest of their food once they’ve eaten the medicated part.
7. Store the powder in a cool, dry place with the lid closed tightly.

Never give powder straight into your pet’s mouth—it can be dangerous if inhaled.

This compounded formulation combines two active ingredients from different drug classes: omeprazole, a proton pump inhibitor and misoprostol, a prostaglandin analog. In compounding practice, clinicians may consider a combination like this to address the gastric environment through more than one mechanism. Your veterinarian determines whether it is appropriate based on your animal's history and diagnostic findings.

At a pharmacological level, omeprazole binds to the hydrogen-potassium ATPase enzyme system—the "proton pump"—within the gastric parietal cells, which suppresses the final step of acid secretion into the stomach lumen. Misoprostol is a synthetic prostaglandin analog that binds to prostaglandin receptors on parietal cells, further reducing acid secretion while supporting mucosal blood flow and the secretion of protective bicarbonate and mucus. Together, the two ingredients act on the gastric environment through complementary mechanisms.

This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.

Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.

Commonly observed effects of omeprazole/misoprostol may include mild gastrointestinal changes such as loose stools, flatulence or transient colic-like symptoms shortly after administration. Because misoprostol can influence uterine contractions, this medication is typically used with extra caution or avoided in pregnant mares, as it is associated with a risk of abortion. Owners who are pregnant or may become pregnant should exercise extreme care and wear non-porous protective gloves (such as chemical-resistant nitrile or neoprene) when handling this medication to avoid accidental skin absorption.

This medication is typically avoided in patients with a known hypersensitivity to either omeprazole or misoprostol. It is important to provide your veterinarian with a complete history of all other prescriptions and supplements your horse is receiving, as changes in gastric pH can influence the absorption of other oral medications. Your veterinarian will provide specific guidance on the timing of administration relative to feeding to ensure the protocol remains suitable for your horse's individual needs. Contact your veterinarian promptly if you observe significant behavioral changes, persistent diarrhea or any signs of physical discomfort during the administration period.