Notieup (Potassium CHLORIDE + Magnesium Chloride + Niacin + Arginine HCl + L-Lysine HCl + Cyanocobalamin) Injectable

Giving your pet an injection might feel intimidating at first, but with practice, it becomes routine. Follow these steps for safe and stress-free injections.

Get Your Supplies Ready

1. Medication vial or pre-filled syringe
2. Alcohol swabs
3. Sterile syringe & needle (if not pre-filled)
4. Sharps container for safe needle disposal

Drawing Up the Dose (if needed)

1. Clean the vial top with an alcohol swab
2. Attach needle to syringe
3. Pull in air equal to the dose
4. Insert needle into vial, push air in
5. Draw out the correct dose
6. Tap out air bubbles

Pick the Injection Site

1. Subcutaneous (under the skin): Loose skin between shoulder blades or side
2. Intramuscular (into muscle): As directed by your vet

Prep the Area

1. Pinch a fold of skin to form a “tent” (for subcutaneous). Wipe with alcohol if recommended.

Inject the Medication

1. Hold the syringe like a pencil
2. Insert the needle into the base of the skin tent at a 45° angle
3. Push the plunger slowly to inject

After the Injection

1. Remove the needle smoothly
2. Place it immediately in the sharps container (don’t recap)
3. Pat the area and give your pet praise or a treat

Safety Tips

1. Never reuse needles
2. Always dispose of used needles properly
3. Ask your vet for help if unsure

This is a compounded preparation combining the active ingredients listed in the product name. In compounding practice, clinicians may consider a multi-ingredient preparation like this to address more than one aspect of a patient's physiology at once. Your veterinarian determines whether it is appropriate for your animal.

At a pharmacological level, the components of Notieup act through several distinct pathways to address the cellular environment. Potassium and magnesium chloride are vital electrolytes that support normal neuromuscular signaling and enzymatic reactions. Arginine and L-lysine are essential amino acids involved in protein synthesis and the modulation of metabolic byproducts. Niacin and cyanocobalamin (Vitamin B12) function as vital coenzymes in energy metabolism and are essential for normal neurological health. This formulation is typically intended for slow intravenous administration, allowing these active ingredients to be immediately available to the horse’s metabolic processes. Your veterinarian will determine if Notieup is appropriate based on your horse’s weight, health status and the specific requirements of the clinical context.

This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.

Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.

Commonly observed effects following the administration of concentrated parenteral support include localized site irritation at the point of injection or transient behavioral changes as the body adjusts to the infusion. Because Notieup contains concentrated electrolytes, it must be administered at a rate and volume determined by your veterinarian to avoid physiological complications such as cardiac rhythm shifts. In some patients, rapid administration may be associated with sweating, restlessness or an increased respiratory rate. If you observe persistent swelling at the injection site or if your horse appears distressed following administration, contact your veterinarian promptly.

This product is typically used with extra caution or avoided in horses with known kidney impairment, as the kidneys are responsible for the regulation and excretion of potassium and magnesium. It is also used carefully in horses with a history of hypersensitivity to injectable vitamin or mineral products. Before starting a protocol involving Notieup, ensure your veterinarian has a complete history of all other prescriptions and supplements your horse is receiving to avoid potential electrolyte imbalances. Always follow the professional guidance provided by your veterinarian regarding the timing of administration and any necessary patient monitoring during the recovery period.