Neomycin/Polymixin/GRAMicidin Ophthalmic Solution
Neomycin/Polymixin/GRAMicidin is a compounded formulation containing Neomycin, Polymixin, GRAMicidin, prepared by Mixlab for veterinary use. Available by prescription.
How to Give Your Pet Eye Drops (Ophthalmic Solutions)
Eye drops are liquid medications used to treat your pet’s eye conditions. They’re clear, gentle, and effective with the right technique. With a bit of practice, you and your pet will get the hang of it!
Step-by-Step Guide:
- Wash Your Hands: Start clean to avoid germs.
- Get Your Pet Comfortable: Sit your dog or wrap your cat in a towel (“kitty burrito”) to keep them still. A helper can gently steady the head.
- Clean the Eye (if needed): Use a damp cotton ball or gauze to gently wipe any discharge.
- Position the Bottle: Hold the bottle in your dominant hand. Use the other hand to tilt your pet’s head and gently pull down the lower eyelid to create a small pocket.
- Apply the Drops: Hold the bottle close (but not touching the eye) and squeeze in the prescribed number of drops. Aim for the center of the eye or into the pocket.
- Let Your Pet Blink: Blinking helps spread the medication. Gently blot away excess drops.
- Repeat for the Other Eye (if needed): Use the same care and steps.
- Prevent Rubbing: Hold your pet briefly to stop rubbing. Offer gentle praise or a treat!
- Multiple Eye Meds?: Wait 5–10 minutes between different meds. Use watery drops before thicker ointments, unless told otherwise.
- Store Properly: Recap the bottle and store it as directed (usually at room temp).
This compounded formulation combines active ingredients from different drug classes: neomycin, an aminoglycoside antibiotic; polymixin, a polymyxin antibiotic; and gramicidin, a topical antibiotic. In compounding practice, clinicians may consider a multi-ingredient preparation like this to address more than one aspect of a patient's physiology at once. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.
This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
At a pharmacological level, these three agents are considered to influence the bacterial population through protein synthesis inhibition and cell membrane disruption. Commonly observed effects include localized changes at the site of application such as temporary stinging, squinting or redness. Because it is intended for ophthalmic use, your veterinarian will provide training on the proper technique to avoid contaminating the dropper tip. Owners should monitor for any persistent ocular discharge or cloudiness and contact their veterinarian promptly.
Yes. This antibiotic combination is a prescription ophthalmic medication and requires a valid authorization from a licensed veterinarian. Mixlab ensures all professional standards are met.
Yes. While available in commercial eye drops, Mixlab specializes in compounding these active ingredients into specialized sterile vehicles if a customized preparation better suits your pet's ophthalmic needs.
Veterinarians may consider combining these ingredients so the preparation can act through more than one mechanism at once — here, it focuses on antibacterial action. Your veterinarian determines whether this multi-targeted approach is appropriate for your pet.
Your veterinarian will provide professional guidance on the administration schedule. It is important to avoid touching the dropper tip to any surface, including your pet's eye, to maintain sterility.
If you notice increased squinting, swelling or a change in eye color, contact your veterinarian immediately. They will perform a professional exam to ensure the management approach remains suitable.
