Mirtazapine/PrednisoLONE Transdermal Pen (1.5mL)
A combination of Mirtazapine and PrednisoLONE is sometimes used off-label in veterinary medicine, particularly in cats and dogs, for conditions where both appetite stimulation and anti-inflammatory or immunosuppressive effects are needed.
A transdermal pen is a simple way to give your pet medicine through their skin—usually used for cats by applying gel to the inside of their ear.
Step-by-Step:
- Get the pen ready – Twist the pen to dispense a small amount of gel. If it’s your first time, you will need to “prime” it first (the gel should be flush with the edge of the tip)
- Wear gloves – Always use a disposable glove or finger cot so the medication doesn’t absorb into your skin.
- Twist to dose – Follow the pen’s directions (like two full twists) to get the right amount of gel out. Always click in a clockwise direction, clicking counter-clockwise will stop you
- Pick the spot – Apply to a hairless area, usually the inside of your cat’s ear. Make sure the area is clean and dry.
- Apply the gel – Dab the gel directly with the pen or use your gloved finger to rub it in gently. Avoid the ear canal.
- Let it dry – It usually dries in a minute or two. Try to keep your pet from rubbing it off.
- Recap the pen – This keeps the medication fresh.
- Wash your hands – Even if you wore gloves, wash thoroughly after.
- Reward your pet – A treat helps make it a stress-free routine!
- Store properly – Keep at room temp, away from sunlight. Track doses so you know when it’s time to refill.
Important: Only apply where your vet has directed—usually hairless areas. Never apply over fur or broken skin. Keep other pets from licking the area until it’s dry.
This compounded formulation combines mirtazapine, an appetite stimulant, with prednisolone, a corticosteroid — two different drug classes. In compounding practice, clinicians may consider a combination like this for a multi-targeted approach. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.
This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
At a pharmacological level, mirtazapine is considered to influence appetite signaling while prednisolone is considered to influence the inflammatory response. Commonly observed effects include behavioral shifts such as increased thirst, increased urination (polyuria/polydipsia) and temporary vocalization or restlessness. Because both ingredients can influence metabolic and neurological systems, your veterinarian will monitor for observational signs of steroid influence. Owners should monitor for significant behavioral changes and contact their veterinarian promptly with any concerns regarding the patient's response.
Yes. This combination requires a valid prescription from a licensed veterinarian before it can be dispensed. Mixlab verifies all professional authorizations before preparing any medication.
Yes. Mixlab specializes in compounding mirtazapine and prednisolone into customized strengths and flavored oral formats, such as flavored oral liquids or treats, to suit your pet's needs. The decision rests with your prescribing veterinarian.
Veterinarians discuss this combination for pets whose inflammatory conditions are accompanied by a lack of appetite. This dual approach provides a method for addressing both the physical inflammation and the patient's nutritional intake.
Commonly observed effects include increased hunger from both agents and potential restlessness. Report any unusual weakness or extreme behavioral shifts to your veterinarian for a clinical review.
Both components are typically tapered off gradually under professional guidance. Your veterinarian is the right person to provide a proper schedule to ensure the management approach remains safe for your pet.
