Maropitant/Mirtazapine Transdermal Pen (1.5mL)
Maropitant/Mirtazapine is a compounded formulation containing Maropitant, Mirtazapine, prepared by Mixlab for veterinary use. Available by prescription.
A transdermal pen is a simple way to give your pet medicine through their skin—usually used for cats by applying gel to the inside of their ear.
Step-by-Step:
- Get the pen ready – Twist the pen to dispense a small amount of gel. If it’s your first time, you will need to “prime” it first (the gel should be flush with the edge of the tip)
- Wear gloves – Always use a disposable glove or finger cot so the medication doesn’t absorb into your skin.
- Twist to dose – Follow the pen’s directions (like two full twists) to get the right amount of gel out. Always click in a clockwise direction, clicking counter-clockwise will stop you
- Pick the spot – Apply to a hairless area, usually the inside of your cat’s ear. Make sure the area is clean and dry.
- Apply the gel – Dab the gel directly with the pen or use your gloved finger to rub it in gently. Avoid the ear canal.
- Let it dry – It usually dries in a minute or two. Try to keep your pet from rubbing it off.
- Recap the pen – This keeps the medication fresh.
- Wash your hands – Even if you wore gloves, wash thoroughly after.
- Reward your pet – A treat helps make it a stress-free routine!
- Store properly – Keep at room temp, away from sunlight. Track doses so you know when it’s time to refill.
Important: Only apply where your vet has directed—usually hairless areas. Never apply over fur or broken skin. Keep other pets from licking the area until it’s dry.
This compounded formulation combines maropitant, an NK1-receptor antagonist antiemetic, with mirtazapine, an appetite stimulant — two different drug classes. In compounding practice, clinicians may consider a combination like this for a multi-targeted approach. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.
This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
At a pharmacological level, maropitant is considered for its role in managing the vomiting center in the brain while mirtazapine is considered to influence serotonin and norepinephrine receptors in ways associated with appetite stimulation. Commonly observed effects include behavioral shifts such as temporary lethargy or increased vocalization and localized digestive changes. Because it influences neurological signaling, your veterinarian will monitor for observational signs of sensitivity, especially in pets with known hepatic or renal impairment. Owners should monitor for significant behavioral shifts and contact their veterinarian promptly.
Yes. This combination of maropitant and mirtazapine is a prescription medication and requires a valid authorization from a licensed veterinarian. Mixlab verifies all legal authorizations.
Yes. Mixlab specializes in compounding maropitant and mirtazapine into customized strengths and flavored oral formats, such as flavored oral liquids or treats, to support easier administration.
Veterinarians discuss this combination for pets presented with both a lack of appetite and nausea. By addressing both the vomiting reflex and hunger signaling in the brain, it provides a method for supporting recovery.
Commonly observed effects of mirtazapine can include increased energy or vocalization in some cats. Your veterinarian will provide guidance on what behavioral shifts are expected during the course of management.
Both medications are processed by the body's organs. Your veterinarian will determine if this management approach is appropriate based on your cat's renal and hepatic status and provide a specific monitoring schedule.
