MARBOfloxacin/Miconazole/Dexamethasone clEARmix Thermo Gel Otic (3mL Syringe)
MARBOfloxacin/Miconazole/Dexamethasone is a compounded formulation containing MARBOfloxacin, Miconazole, Dexamethasone, prepared by Mixlab for veterinary use. Available by prescription.
How to Use clEARmix Thermo Gel Otic (Ear Medication)
This is a liquid ear medication that turns into a gel once it warms up in your pet’s ear, helping it stay in place and work effectively. It comes in a soft-tipped syringe for easy use.
Step-by-Step:
- Keep it cool – Store in the fridge if instructed. Before using, hold the syringe in your hands for a minute so it’s not too cold, but don’t warm it too much.
- Get your pet ready – Have them sit comfortably and gently lift the ear flap. A second person can help hold them still if needed.
- Clean the ear (if advised) – Use a vet-approved ear cleaner and cotton ball. Wipe out any debris and let the ear dry.
- Apply the medication – Take off the cap. Gently insert just the tip into the ear opening (not deep), and slowly press the plunger to deliver the full dose.
- Massage the ear – Rub the base of the ear for 30 seconds. The liquid will turn into a gel as it warms, and massaging helps it spread inside the ear.
- Let them shake it out – It’s normal! Wipe away any extra gel you see near the ear opening.
- Reward your pet – Offer praise or a treat to keep the experience positive.
- Store and clean up – Recap the syringe and refrigerate if needed. Wash your hands afterward.
This compounded formulation combines active ingredients from different drug classes: marbofloxacin, a fluoroquinolone antibiotic; miconazole, an azole antifungal; and dexamethasone, a corticosteroid. In compounding practice, clinicians may consider a multi-ingredient preparation like this to address more than one aspect of a patient's physiology at once. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.
This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
At a pharmacological level, marbofloxacin is considered for its influence on bacterial DNA while miconazole is considered for its influence on fungal cell membranes and dexamethasone is considered for its role in modulating the inflammatory response. Commonly observed effects include localized changes such as mild redness, temporary discharge or increased sensitivity. Because the formulation contains dexamethasone, your veterinarian will monitor for observational signs of systemic steroid influence, such as shifts in thirst or appetite. Ensuring the eardrum is intact is a high-priority clinical consideration. Owners should monitor their pet for any unusual behavioral shifts and contact their veterinarian promptly.
Yes. This combination requires a valid prescription from a licensed veterinarian before it can be dispensed. Mixlab verifies all professional authorizations before preparing any medication.
Yes. Mixlab specializes in compounding the combination of marbofloxacin, miconazole and dexamethasone into customized otic suspensions tailored to the specific needs of your pet's ears.
Veterinarians may consider combining these ingredients so the preparation can act through more than one mechanism at once — here, it brings together antibacterial, antifungal and anti-inflammatory actions in one preparation. Your veterinarian determines whether this multi-targeted approach is appropriate for your pet.
Your veterinarian will provide specific instructions on the administration schedule and the proper technique for cleaning the ear. Following professional guidance helps ensure the medication reaches the site of concern.
You should monitor for observational signs like decreased redness and improved comfort. If you notice your pet rubbing their ear excessively or holding their head tilted, contact your veterinarian for a clinical review.
