Gabapentin/Trazodone Oral Suspension (Anhydrous)
Gabapentin/Trazodone is a compounded formulation containing Gabapentin, Trazodone, prepared by Mixlab for veterinary use. Available by prescription.
How to Give Anhydrous Oral Suspension
Oral Suspension (Anhydrous) is a liquid medication that does not contain water in its base. This might be an oil-based or other special base to help stabilize the medicine. It will look like a regular liquid medication, but often needs a good shake because the drug can settle. Here's how to give it:
- Shake well each time to mix the medication (5-10 seconds).
- Measure the dose using the syringe/dropper provided or one recommended by your vet. Insert the top of the oral syringe into the bottle adapter. Turn the bottle upside down and pull the plunger until the medicine reaches the volume required
- Hold your pet steady: a towel or helper can assist with squirmy pets.
- Administer the dose slowly into the side of the mouth. Allow small pauses if needed for swallowing.
- Raise the head slightly to help the medication go down and clean any spills with a little water or tissue.
- Praise your pet and offer a treat or water (unless advised against feeding right after).
- Clean the syringe with water immediately after use. Store the bottle as directed, out of sunlight.
- Consistency is key: Shake each time, measure accurately, and contact your vet if any issues arise.
This compounded formulation combines gabapentin, a neuropathic-pain and calming agent, with trazodone, a calming agent (serotonin modulator) — two different drug classes. In compounding practice, clinicians may consider a combination like this for a multi-targeted approach. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.
This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
At a pharmacological level, gabapentin manages neuronal excitability while trazodone manages serotonin concentrations at the synaptic cleft. Commonly observed effects include behavioral shifts such as significant sedation, lethargy or coordination changes. Because both ingredients influence the central nervous system, your veterinarian will monitor for observational signs of extreme drowsiness. Owners should monitor for any unusual behavioral changes or persistent digestive distress and contact their veterinarian promptly with any concerns regarding the patient's response.
Yes. This combination requires a valid prescription from a licensed veterinarian before it can be dispensed. Mixlab verifies all professional authorizations before preparing any medication.
Yes. Mixlab specializes in compounding gabapentin and trazodone into customized strengths and flavored oral formats, such as flavored oral liquids or treats, to support easier administration. The decision rests with your prescribing veterinarian.
Veterinarians discuss this combination for situational triggers like travel or veterinary visits because it provide a method for managing your pet's stress response. It is often considered when a single medication has not been suitable.
Your veterinarian will provide specific guidance on the administration schedule based on the situational trigger. They may recommend a "test dose" at home first to monitor your pet’s individual behavioral response.
These medications are intended to manage acute stress and reactivity rather than permanently alter behavior. Your veterinarian will provide guidance on the necessary duration of use and proper monitoring for your pet.
