FLUOXetine/Prazosin HCl Transdermal Pen (9mL)
FLUOXetine/Prazosin HCl is a compounded formulation containing FLUOXetine, Prazosin HCl, prepared by Mixlab for veterinary use. Available by prescription.
A transdermal pen is a simple way to give your pet medicine through their skin—usually used for cats by applying gel to the inside of their ear.
Step-by-Step:
- Get the pen ready – Twist the pen to dispense a small amount of gel. If it’s your first time, you will need to “prime” it first (the gel should be flush with the edge of the tip)
- Wear gloves – Always use a disposable glove or finger cot so the medication doesn’t absorb into your skin.
- Twist to dose – Follow the pen’s directions (like two full twists) to get the right amount of gel out. Always click in a clockwise direction, clicking counter-clockwise will stop you
- Pick the spot – Apply to a hairless area, usually the inside of your cat’s ear. Make sure the area is clean and dry.
- Apply the gel – Dab the gel directly with the pen or use your gloved finger to rub it in gently. Avoid the ear canal.
- Let it dry – It usually dries in a minute or two. Try to keep your pet from rubbing it off.
- Recap the pen – This keeps the medication fresh.
- Wash your hands – Even if you wore gloves, wash thoroughly after.
- Reward your pet – A treat helps make it a stress-free routine!
- Store properly – Keep at room temp, away from sunlight. Track doses so you know when it’s time to refill.
Important: Only apply where your vet has directed—usually hairless areas. Never apply over fur or broken skin. Keep other pets from licking the area until it’s dry.
This compounded formulation combines fluoxetine, a selective serotonin reuptake inhibitor (SSRI), with prazosin, an alpha-adrenergic blocker — two different drug classes. In compounding practice, clinicians may consider a combination like this for a multi-targeted approach. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.
This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
At a pharmacological level, fluoxetine manages serotonin reuptake while prazosin manages the tone of smooth muscle in the bladder neck and urethra. Commonly observed effects include behavioral shifts such as lethargy and localized cardiovascular changes like low blood pressure (hypotension). Because it influences both behavior and vascular tone, your veterinarian will monitor for observational signs of weakness or fainting. Owners should monitor for significant behavioral shifts and contact their veterinarian promptly with any concerns regarding the patient's response.
Yes. This combination of fluoxetine and prazosin is a prescription medication and requires a valid authorization from a licensed veterinarian. Mixlab verifies all legal requirements.
Yes. Mixlab specializes in compounding fluoxetine and prazosin into customized strengths and flavored oral formats, such as flavored oral liquids, to support easier administration. The decision rests with your prescribing veterinarian.
Veterinarians discuss this combination for conditions like stress-related urinary challenges in cats. By managing both the neurological stress response and the physical muscle tone of the urinary tract, it provides a method for management.
Lethargy is a commonly observed effect of both fluoxetine and prazosin. Your veterinarian will provide guidance on what level of drowsiness is expected and how to monitor your pet's energy levels.
Weakness can be an observational sign of low blood pressure associated with prazosin. If you notice your pet appearing unusually unsteady or fainting, contact your veterinarian immediately for a clinical review.
