Estrumate (Cloprostenol Sodium), Prostaglandin Analogue Injectable

Giving your pet an injection might feel intimidating at first, but with practice, it becomes routine. Follow these steps for safe and stress-free injections.

Get Your Supplies Ready

1. Medication vial or pre-filled syringe
2. Alcohol swabs
3. Sterile syringe & needle (if not pre-filled)
4. Sharps container for safe needle disposal

Drawing Up the Dose (if needed)

1. Clean the vial top with an alcohol swab
2. Attach needle to syringe
3. Pull in air equal to the dose
4. Insert needle into vial, push air in
5. Draw out the correct dose
6. Tap out air bubbles

Pick the Injection Site

1. Subcutaneous (under the skin): Loose skin between shoulder blades or side
2. Intramuscular (into muscle): As directed by your vet

Prep the Area

1. Pinch a fold of skin to form a “tent” (for subcutaneous). Wipe with alcohol if recommended.

Inject the Medication

1. Hold the syringe like a pencil
2. Insert the needle into the base of the skin tent at a 45° angle
3. Push the plunger slowly to inject

After the Injection

1. Remove the needle smoothly
2. Place it immediately in the sharps container (don’t recap)
3. Pat the area and give your pet praise or a treat

Safety Tips

1. Never reuse needles
2. Always dispose of used needles properly
3. Ask your vet for help if unsure

This compounded formulation contains estrumate prostaglandin analogue. In compounding practice, clinicians may consider it based on the established properties of the active ingredient. Your veterinarian determines whether it is appropriate for your animal.

This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.

Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.

Commonly observed effects of Estrumate administration, particularly in horses, include transient sweating, increased respiratory rate and mild abdominal discomfort or colic-like symptoms. These effects typically appear within minutes of administration and are often self-limiting, though owners should monitor the patient closely. In cattle, site reactions or localized swelling may occur. A critical safety point involves human handling: Estrumate can be absorbed through the skin and is associated with significant respiratory and reproductive risks in humans, particularly those with asthma or those who are pregnant. Because of this, anyone handling the medications must wear non-porous protective gloves (such as chemical-resistant nitrile or neoprene) and avoid direct contact or inhalation. If you observe persistent physical distress in your animal or if accidental human exposure occurs, contact your veterinarian or a medical professional promptly.

This medication is typically used with extra caution or avoided in animals with known respiratory conditions, such as acute or chronic bronchoconstriction, as prostaglandins can influence airway diameter. It is also strictly evaluated in pregnant animals where maintaining the pregnancy is the goal, as Estrumate is associated with unintended termination of pregnancy. Before starting a protocol, ensure your veterinarian has a complete history of all other prescriptions and supplements your animal is receiving. Your veterinarian is the right person to design a comprehensive monitoring plan and provide guidance on the necessary duration of use to ensure the management approach remains suitable for your animal's health status.