Enalapril/Spironolactone Oral Suspension (Anhydrous)
Enalapril/Spironolactone is a compounded formulation containing Enalapril, Spironolactone, prepared by Mixlab for veterinary use. Available by prescription.
How to Give Anhydrous Oral Suspension
Oral Suspension (Anhydrous) is a liquid medication that does not contain water in its base. This might be an oil-based or other special base to help stabilize the medicine. It will look like a regular liquid medication, but often needs a good shake because the drug can settle. Here's how to give it:
- Shake well each time to mix the medication (5-10 seconds).
- Measure the dose using the syringe/dropper provided or one recommended by your vet. Insert the top of the oral syringe into the bottle adapter. Turn the bottle upside down and pull the plunger until the medicine reaches the volume required
- Hold your pet steady: a towel or helper can assist with squirmy pets.
- Administer the dose slowly into the side of the mouth. Allow small pauses if needed for swallowing.
- Raise the head slightly to help the medication go down and clean any spills with a little water or tissue.
- Praise your pet and offer a treat or water (unless advised against feeding right after).
- Clean the syringe with water immediately after use. Store the bottle as directed, out of sunlight.
- Consistency is key: Shake each time, measure accurately, and contact your vet if any issues arise.
This compounded formulation combines enalapril, an ACE inhibitor, with spironolactone, an aldosterone-antagonist diuretic — two different drug classes. In compounding practice, clinicians may consider a combination like this for a multi-targeted approach. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.
This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
Commonly observed effects include behavioral shifts such as increased thirst and urination, as well as localized digestive changes like vomiting or a temporary decrease in appetite. Because both ingredients influence renal function and electrolyte balance, your veterinarian will monitor for observational signs of high blood potassium (hyperkalemia) or kidney stress. It is typically used with caution in patients with known severe renal impairment. Owners should monitor their pet for any unusual lethargy or significant shifts in activity levels and contact their veterinarian promptly with any concerns.
Yes. Enalapril and spironolactone is a prescription medication combination and requires a valid authorization from a licensed veterinarian. Mixlab verifies all legal requirements before any medication is prepared or shipped.
Yes. Mixlab specializes in compounding enalapril and spironolactone into customized strengths and flavored oral formats, such as flavored liquids or capsules, to suit your pet's needs. The decision rests with your prescribing veterinarian.
Veterinarians discuss this combination because it manages the cardiovascular system through two different pathways. While one manages blood pressure, the other manages hormones that can cause long-term structural changes to the heart muscle.
Your veterinarian will recommend periodic blood tests to monitor kidney values and electrolyte levels, specifically potassium. This monitoring ensures the management approach remains appropriate for your pet's heart health.
This combination is often part of a broader protocol that may include other diuretics or inotropes. Your veterinarian will determine the most appropriate combination of medications based on your pet's specific cardiac needs.
