Doxycycline (as Hyclate)/Gentamicin/Triamcinolone clEARmix Thermo Gel Otic (3mL Syringe)
Doxycycline (as Hyclate)/Gentamicin/Triamcinolone is a compounded formulation containing doxycycline (as hyclate), gentamicin and triamcinolone, prepared by Mixlab for veterinary use. Available by prescription.
How to Use clEARmix Thermo Gel Otic (Ear Medication)
This is a liquid ear medication that turns into a gel once it warms up in your pet’s ear, helping it stay in place and work effectively. It comes in a soft-tipped syringe for easy use.
Step-by-Step:
- Keep it cool – Store in the fridge if instructed. Before using, hold the syringe in your hands for a minute so it’s not too cold, but don’t warm it too much.
- Get your pet ready – Have them sit comfortably and gently lift the ear flap. A second person can help hold them still if needed.
- Clean the ear (if advised) – Use a vet-approved ear cleaner and cotton ball. Wipe out any debris and let the ear dry.
- Apply the medication – Take off the cap. Gently insert just the tip into the ear opening (not deep), and slowly press the plunger to deliver the full dose.
- Massage the ear – Rub the base of the ear for 30 seconds. The liquid will turn into a gel as it warms, and massaging helps it spread inside the ear.
- Let them shake it out – It’s normal! Wipe away any extra gel you see near the ear opening.
- Reward your pet – Offer praise or a treat to keep the experience positive.
- Store and clean up – Recap the syringe and refrigerate if needed. Wash your hands afterward.
This compounded formulation combines active ingredients from different drug classes: doxycycline, a tetracycline antibiotic; gentamicin, an aminoglycoside antibiotic; and triamcinolone, a corticosteroid. In compounding practice, clinicians may consider a multi-ingredient preparation like this to address more than one aspect of a patient's physiology at once. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.
This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
Commonly observed effects include localized changes at the application site, such as mild redness or temporary discharge. Because the formulation contains a corticosteroid, systemic absorption is possible; your veterinarian will monitor for observational signs of steroid influence such as increased thirst or urination. Ensuring the eardrum is intact is a high-priority clinical consideration before use. Owners should watch for behavioral shifts including a head tilt or loss of balance and contact their veterinarian promptly with any concerns.
Yes. This is a prescription medication and can only be dispensed by a licensed pharmacy upon receipt of a valid authorization from a licensed veterinarian. Mixlab verifies all legal authorizations before preparing any medication.
Yes. Mixlab specializes in compounding this triple-agent combination into customized otic suspensions to suit the specific needs of your pet. The decision to utilize a compounded formulation rests with the prescribing veterinarian.
Veterinarians may consider combining these ingredients so the preparation can act through more than one mechanism at once — here, it brings together antibacterial and anti-inflammatory actions in one preparation. Your veterinarian determines whether this multi-targeted approach is appropriate for your pet.
Your veterinarian will likely recommend wearing gloves and washing your hands thoroughly after handling the medication. It is important to avoid direct contact with the treated area until it has been absorbed.
Veterinarians typically recommend a follow-up exam to confirm your pet is responding as expected. This provides a method for determining the appropriate duration of the management approach.
