Diclazuril/Levamisole HCl/Vitamin E Succinate Paste
Diclazuril/Levamisole HCl/Vitamin E Succinate is a compounded oral formulation containing diclazuril, levamisole hydrochloride and vitamin E succinate, prepared by Mixlab for veterinary use in horses. Available by prescription.
Paste medications are thick and sticky, usually given by mouth using a syringe or tube. They’re often used for dewormers or other oral meds in horses, dogs, and cats. The key is to aim for the back of the mouth so your pet swallows the paste instead of spitting it out.
For Horses:
- Set the dose on the syringe if it has markings (usually based on weight).
- Stand beside your horse, not in front, and have someone hold them if possible.
- Gently insert your thumb into the side of the horse’s mouth (between the teeth) to open it.
- Insert the syringe into that gap and squirt the paste toward the back of the tongue.
- Lift the horse’s head slightly and encourage swallowing by stroking the throat or gently blowing on the nostrils.
- Watch for licking or chewing—that means they swallowed. If paste spills out, check how much was lost and contact your vet if unsure.
- You can offer a little water afterward and reward them with a treat like a carrot if allowed.
For Dogs & Cats:
- Gently open your pet’s mouth or slip the syringe into the side of it.
- Aim toward the back of the tongue and squirt the paste in.
- Hold the mouth closed briefly, and rub the throat or blow gently on the nose to encourage swallowing.
- Give praise or a treat afterward to make it a positive experience.
Aftercare:
- Wipe your pet’s mouth if needed.
- Clean or recap the syringe as instructed.
- Store the tube according to label directions.
Tip: Paste can feel weird to pets at first. For horses, try giving applesauce by syringe ahead of time so they get used to the sensation.
This compounded formulation combines three active ingredients from different classes: diclazuril (an antiprotozoal), levamisole (an agent with immunomodulatory properties) and vitamin E succinate (an antioxidant). In compounding practice, clinicians may consider a multi-component preparation like this to address more than one aspect of a patient's physiology at once. Your veterinarian determines whether it is appropriate based on your horse's status and diagnostic findings.
At a pharmacological level, the three components act through distinct mechanisms. Diclazuril is a benzeneacetonitrile antiprotozoal that inhibits specific stages of a parasite's life cycle, disrupting its ability to replicate. Levamisole is primarily an anthelmintic but is included here for its immunomodulatory properties, as it may influence the cellular immune response. Vitamin E succinate is a fat-soluble antioxidant that acts at the cellular level to support tissues against oxidative stress.
This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
Commonly observed effects of this combination may include mild gastrointestinal upset, changes in appetite or transient loose stools. In some patients receiving levamisole, owners may observe mild behavioral changes or restlessness. Because neurological conditions can be sensitive to physiological changes, your veterinarian will monitor for any shifts in coordination or alertness. If you observe significant changes in your horse's gait, stumbling or persistent lethargy, contact your veterinarian promptly to share these observations.
This medication is typically used with caution in pregnant or lactating mares, as the effects of certain components on developing foals have not been fully characterized. It is essential to provide your veterinarian with a complete history of all other prescriptions and supplements your horse is receiving, as concurrent use of other medications can influence the overall metabolic profile. Your veterinarian is the best resource for designing a comprehensive management plan—which may include environmental modifications—to support your horse during the administration period.
Yes. This combination is a prescription medication and can only be dispensed by a licensed pharmacy upon receipt of a valid authorization from a licensed veterinarian. Mixlab verifies all prescriptions before any medication is prepared or dispensed.
Yes. This specific triple-combination is typically available as a compounded preparation, allowing Mixlab to provide it in a format—such as an oral paste or powder—that facilitates administration for your horse. Your veterinarian will determine the most appropriate formulation based on your animal's individual needs.
While levamisole is often categorized as a dewormer, veterinarians consider it in this context for its potential immunomodulatory effects. It is discussed as a way to support the horse’s natural immune response during the management of protozoal challenges.
Vitamin E is an antioxidant that veterinarians often include to support cellular health. In this combination, it acts by helping to manage oxidative stress in the tissues.
