Diclazuril/Levamisole HCl/Vitamin E Succinate Oral Suspension (Anhydrous)
Diclazuril/Levamisole HCl/Vitamin E Succinate is a compounded oral formulation containing diclazuril, levamisole hydrochloride and vitamin E succinate, prepared by Mixlab for veterinary use in horses. Available by prescription.
How to Give Anhydrous Oral Suspension
Oral Suspension (Anhydrous) is a liquid medication that does not contain water in its base. This might be an oil-based or other special base to help stabilize the medicine. It will look like a regular liquid medication, but often needs a good shake because the drug can settle. Here's how to give it:
- Shake well each time to mix the medication (5-10 seconds).
- Measure the dose using the syringe/dropper provided or one recommended by your vet. Insert the top of the oral syringe into the bottle adapter. Turn the bottle upside down and pull the plunger until the medicine reaches the volume required
- Hold your pet steady: a towel or helper can assist with squirmy pets.
- Administer the dose slowly into the side of the mouth. Allow small pauses if needed for swallowing.
- Raise the head slightly to help the medication go down and clean any spills with a little water or tissue.
- Praise your pet and offer a treat or water (unless advised against feeding right after).
- Clean the syringe with water immediately after use. Store the bottle as directed, out of sunlight.
- Consistency is key: Shake each time, measure accurately, and contact your vet if any issues arise.
This compounded formulation combines three active ingredients from different classes: diclazuril (an antiprotozoal), levamisole (an agent with immunomodulatory properties) and vitamin E succinate (an antioxidant). In compounding practice, clinicians may consider a multi-component preparation like this to address more than one aspect of a patient's physiology at once. Your veterinarian determines whether it is appropriate based on your horse's status and diagnostic findings.
At a pharmacological level, the three components act through distinct mechanisms. Diclazuril is a benzeneacetonitrile antiprotozoal that inhibits specific stages of a parasite's life cycle, disrupting its ability to replicate. Levamisole is primarily an anthelmintic but is included here for its immunomodulatory properties, as it may influence the cellular immune response. Vitamin E succinate is a fat-soluble antioxidant that acts at the cellular level to support tissues against oxidative stress.
This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
Commonly observed effects of this combination may include mild gastrointestinal upset, changes in appetite or transient loose stools. In some patients receiving levamisole, owners may observe mild behavioral changes or restlessness. Because neurological conditions can be sensitive to physiological changes, your veterinarian will monitor for any shifts in coordination or alertness. If you observe significant changes in your horse's gait, stumbling or persistent lethargy, contact your veterinarian promptly to share these observations.
This medication is typically used with caution in pregnant or lactating mares, as the effects of certain components on developing foals have not been fully characterized. It is essential to provide your veterinarian with a complete history of all other prescriptions and supplements your horse is receiving, as concurrent use of other medications can influence the overall metabolic profile. Your veterinarian is the best resource for designing a comprehensive management plan—which may include environmental modifications—to support your horse during the administration period.
Yes. This combination is a prescription medication and can only be dispensed by a licensed pharmacy upon receipt of a valid authorization from a licensed veterinarian. Mixlab verifies all prescriptions before any medication is prepared or dispensed.
Yes. This specific triple-combination is typically available as a compounded preparation, allowing Mixlab to provide it in a format—such as an oral paste or powder—that facilitates administration for your horse. Your veterinarian will determine the most appropriate formulation based on your animal's individual needs.
While levamisole is often categorized as a dewormer, veterinarians consider it in this context for its potential immunomodulatory effects. It is discussed as a way to support the horse’s natural immune response during the management of protozoal challenges.
Vitamin E is an antioxidant that veterinarians often include to support cellular health. In this combination, it acts by helping to manage oxidative stress in the tissues.
