Diclazuril/Levamisole HCl/Pyrimethamine/SulfaDIAZINE Sodium/Vitamin E Succinate Oral Suspension (Anhydrous)
Diclazuril/Levamisole HCl/Pyrimethamine/SulfaDIAZINE Sodium/Vitamin E Succinate is a compounded formulation containing Diclazuril, Levamisole HCl, Pyrimethamine, SulfaDIAZINE Sodium, Vitamin E Succinate, prepared by Mixlab for veterinary use. Available by prescription.
How to Give Anhydrous Oral Suspension
Oral Suspension (Anhydrous) is a liquid medication that does not contain water in its base. This might be an oil-based or other special base to help stabilize the medicine. It will look like a regular liquid medication, but often needs a good shake because the drug can settle. Here's how to give it:
- Shake well each time to mix the medication (5-10 seconds).
- Measure the dose using the syringe/dropper provided or one recommended by your vet. Insert the top of the oral syringe into the bottle adapter. Turn the bottle upside down and pull the plunger until the medicine reaches the volume required
- Hold your pet steady: a towel or helper can assist with squirmy pets.
- Administer the dose slowly into the side of the mouth. Allow small pauses if needed for swallowing.
- Raise the head slightly to help the medication go down and clean any spills with a little water or tissue.
- Praise your pet and offer a treat or water (unless advised against feeding right after).
- Clean the syringe with water immediately after use. Store the bottle as directed, out of sunlight.
- Consistency is key: Shake each time, measure accurately, and contact your vet if any issues arise.
This compounded formulation combines active ingredients from different drug classes: diclazuril, an antiprotozoal; levamisole, an immunomodulator; pyrimethamine, an antiprotozoal (folate-pathway inhibitor); sulfadiazine, a sulfonamide antibacterial; and vitamin e, a fat-soluble antioxidant. In compounding practice, clinicians may consider a multi-ingredient preparation like this to address more than one aspect of a patient's physiology at once. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.
At a pharmacological level, the five components act through distinct yet complementary mechanisms. Diclazuril is a benzeneacetonitrile antiprotozoal that disrupts specific stages of the parasite's life cycle. Pyrimethamine and sulfadiazine sodium act synergistically as folate antagonists, inhibiting the synthesis of folic acid which is essential for protozoal DNA replication. Levamisole HCl is frequently discussed in this context for its immunomodulatory properties, as it may influence the cellular immune response of the horse. Vitamin E succinate functions as a potent fat-soluble antioxidant, acting at a cellular level to support the protection of neurological tissues from oxidative stress. Your veterinarian will determine if this specific combination is appropriate based on your horse's weight, neurological status and diagnostic findings.
This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
Commonly observed effects of this combination may include gastrointestinal changes such as loose stools, flatulence or a temporary decrease in appetite. Because this medication contains sulfonamides and folate antagonists, your veterinarian will monitor for signs of hematological changes, such as anemia or a decrease in white blood cell counts. In some horses receiving levamisole, owners may observe mild behavioral changes or localized sweating. If you observe significant changes in your horse's gait, persistent diarrhea or signs of physical distress, contact your veterinarian promptly to share these observations.
This medication is typically used with caution in pregnant or lactating mares, as the effects of several components on developing foals have not been fully characterized. It is essential to provide your veterinarian with a complete history of all other prescriptions and supplements your horse is receiving, as concurrent use of certain medications can influence the overall metabolic and folate profile. Your veterinarian is the best resource for designing a comprehensive approach to monitoring and support during the administration period. Always follow the professional guidance provided regarding the duration of use and the timing of any necessary follow-up laboratory testing.
Yes. This multi-component formulation is a prescription medication and can only be dispensed by a licensed pharmacy like Mixlab upon receipt of a valid authorization from a licensed veterinarian. Mixlab verifies all prescriptions before any medication is prepared or sent to your stable.
Yes. Since this specific five-component blend is not available as a single commercial product, Mixlab compounds it into specialized formats—such as flavored oral pastes or powders—to facilitate administration for your horse. Your veterinarian will determine the most appropriate compounded strength and format based on your animal's individual requirements.
Veterinarians discuss the combination of diclazuril, pyrimethamine and sulfadiazine because they target the protozoal organisms through different pathways. This multimodal approach is considered when a horse requires a more comprehensive strategy to manage the replication and survival of the parasites associated with this condition.
Vitamin E is an essential antioxidant that veterinarians often recommend to support horses with neurological concerns. In this combination, it acts by managing oxidative stress in the tissues, which is a common point of clinical discussion during the management of this condition.
