Dexamethasone/Mupirocin clEARmix Thermo Gel Otic (3mL Syringe)
Dexamethasone/Mupirocin is a compounded formulation containing Dexamethasone, Mupirocin, prepared by Mixlab for veterinary use. Available by prescription.
How to Use clEARmix Thermo Gel Otic (Ear Medication)
This is a liquid ear medication that turns into a gel once it warms up in your pet’s ear, helping it stay in place and work effectively. It comes in a soft-tipped syringe for easy use.
Step-by-Step:
- Keep it cool – Store in the fridge if instructed. Before using, hold the syringe in your hands for a minute so it’s not too cold, but don’t warm it too much.
- Get your pet ready – Have them sit comfortably and gently lift the ear flap. A second person can help hold them still if needed.
- Clean the ear (if advised) – Use a vet-approved ear cleaner and cotton ball. Wipe out any debris and let the ear dry.
- Apply the medication – Take off the cap. Gently insert just the tip into the ear opening (not deep), and slowly press the plunger to deliver the full dose.
- Massage the ear – Rub the base of the ear for 30 seconds. The liquid will turn into a gel as it warms, and massaging helps it spread inside the ear.
- Let them shake it out – It’s normal! Wipe away any extra gel you see near the ear opening.
- Reward your pet – Offer praise or a treat to keep the experience positive.
- Store and clean up – Recap the syringe and refrigerate if needed. Wash your hands afterward.
This compounded formulation combines dexamethasone, a corticosteroid, with mupirocin, a topical antibiotic — two different drug classes. In compounding practice, clinicians may consider a combination like this for a multi-targeted approach. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.
Mupirocin is an antibacterial agent characterized by its unique mechanism of inhibiting bacterial protein synthesis. It acts by binding to the bacterial enzyme isoleucyl-tRNA synthetase, which interferes with the incorporation of isoleucine into peptide chains. This provides a method for managing susceptible gram-positive bacteria, including certain strains that may not respond to other antibiotic classes. By combining these two active ingredients in a single topical vehicle, veterinarians can manage the physiological environment of the skin while simultaneously addressing the bacterial population. Your veterinarian will determine the clinical appropriateness of this combination based on diagnostic findings such as cytology, culture and sensitivity results or a physical examination of the affected area.
This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
Commonly observed effects following the administration of this combination include localized changes at the application site, such as mild redness, discharge or temporary irritation. Because the formulation contains a corticosteroid, systemic absorption is possible; your veterinarian will monitor for observational signs of steroid influence such as increased thirst, changes in appetite or increased urination. In the context of ear administration, ensuring the eardrum is intact is a high-priority clinical consideration as exposure to an intact tympanic membrane is an important safety consideration for inner ear function.
Owners should watch for behavioral shifts including a head tilt, loss of balance or sudden changes in hearing and contact their veterinarian promptly with any concerns regarding their pet’s response to the medication. This medication is typically used with extra caution or avoided in patients with a known hypersensitivity to mupirocin or corticosteroids. It is also carefully evaluated in pets with pre-existing viral or fungal infections of the skin, as steroids can influence the local immune response. Significant interactions can occur if this medication is administered concurrently with other topical agents or specific systemic prescriptions. Your veterinarian is the right person to provide guidance on the necessary duration of use and the proper monitoring schedule to ensure the management approach remains suitable for your pet's recovery.
Yes. This combination contains a potent antibiotic and a corticosteroid and can only be dispensed by a licensed pharmacy upon receipt of a valid authorization from a licensed veterinarian. Mixlab verifies all authorizations before any medication is prepared or shipped to your home.
Yes. Because this specific dual-agent combination is often needed in customized concentrations or specialized vehicles, Mixlab specializes in compounding it into formats such as otic suspensions or topical ointments to suit the specific needs of your pet. The decision between a commercial and compounded product rests with the prescribing veterinarian.
Veterinarians discuss mupirocin because it is an antibiotic that is often active against bacteria that have developed resistance to other treatments. Combining it with a steroid provides a method for managing both the bacterial population and the localized swelling in one application.
Your veterinarian will provide specific instructions on how to safely apply the ointment or drops and how often they are needed. It is important to follow the professional guidance provided and monitor your pet for any unusual signs of discomfort or behavioral changes during the management course.
Your veterinarian will likely recommend wearing unpowdered disposable gloves when applying this medication to your pet's skin or ears. You should also wash your hands thoroughly after handling the medication and avoid direct contact with the treated area until it has been absorbed.
