Cosyntropin Injectable

Giving your pet an injection might feel intimidating at first, but with practice, it becomes routine. Follow these steps for safe and stress-free injections.

Get Your Supplies Ready

1. Medication vial or pre-filled syringe
2. Alcohol swabs
3. Sterile syringe & needle (if not pre-filled)
4. Sharps container for safe needle disposal

Drawing Up the Dose (if needed)

1. Clean the vial top with an alcohol swab
2. Attach needle to syringe
3. Pull in air equal to the dose
4. Insert needle into vial, push air in
5. Draw out the correct dose
6. Tap out air bubbles

Pick the Injection Site

1. Subcutaneous (under the skin): Loose skin between shoulder blades or side
2. Intramuscular (into muscle): As directed by your vet

Prep the Area

1. Pinch a fold of skin to form a “tent” (for subcutaneous). Wipe with alcohol if recommended.

Inject the Medication

1. Hold the syringe like a pencil
2. Insert the needle into the base of the skin tent at a 45° angle
3. Push the plunger slowly to inject

After the Injection

1. Remove the needle smoothly
2. Place it immediately in the sharps container (don’t recap)
3. Pat the area and give your pet praise or a treat

Safety Tips

1. Never reuse needles
2. Always dispose of used needles properly
3. Ask your vet for help if unsure

The uses and pharmacology described below reflect the FDA-approved labeling for this active ingredient; your veterinarian determines whether and how they apply to your animal's treatment plan.

Cosyntropin is a synthetic derivative of the adrenocorticotropic hormone (ACTH) utilized in veterinary medicine primarily as a diagnostic tool. It is a prescription medication available for use in dogs and cats, specifically considered by veterinarians for the performance of ACTH stimulation tests. At a pharmacological level, cosyntropin acts by stimulating the adrenal cortex to produce and secrete cortisol and other adrenal steroids. This action mimics the natural physiological response to endogenous ACTH. By measuring the pet's cortisol levels before and after administration, your veterinarian can manage the diagnostic process for conditions such as hyperadrenocorticism (Cushing’s disease) or hypoadrenocorticism (Addison’s disease). Cosyntropin is characterized by its ability to provide a predictable and standardized adrenal response, providing a method for accurate diagnostic evaluation. Your veterinarian will determine the clinical necessity of cosyntropin based on your pet’s clinical signs and baseline blood work.

Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.

Commonly observed effects following the administration of cosyntropin are rare, as it is typically used as a single dose for diagnostic purposes. Some pets may exhibit localized changes at the injection site or temporary behavioral shifts such as restlessness. While hypersensitivity reactions are uncommon, they have been observed in some individuals. Owners should monitor their pet for any unusual swelling, hives or energy shifts shortly after the diagnostic procedure and contact their veterinarian promptly with any concerns. This medication is typically used in a controlled clinical environment under professional supervision. It is carefully evaluated in pets with a history of hypersensitivity to ACTH or other synthetic proteins. Because cosyntropin influences hormone levels, your veterinarian is the right person to provide guidance on the timing of the test and how the results will inform your pet’s overall management plan.