Constulose (Lactulose) Oral Solution

How to Give Oral Solution

Oral solutions are liquid medications that you give by mouth. In a solution, the medication is completely dissolved in the liquid, so it usually looks clear or evenly colored. Here's how to give it:

1. Shake well each time to mix the medication (5-10 seconds).
2. Measure the dose using the syringe/dropper provided or one recommended by your vet. Insert the top of the oral syringe into the bottle adapter. Turn the bottle upside down and pull the plunger until the medicine reaches the volume required
3. Hold your pet steady: a towel or helper can assist with squirmy pets.
4. Administer the dose slowly into the side of the mouth. Allow small pauses if needed for swallowing.
5. Raise the head slightly to help the medication go down and clean any spills with a little water or tissue.
6. Praise your pet and offer a treat or water (unless advised against feeding right after).
7. Clean the syringe with water immediately after use. Store the bottle as directed, out of sunlight.
8. Consistency is key: Shake each time, measure accurately, and contact your vet if any issues arise.

The uses and pharmacology described below reflect the FDA-approved labeling for this active ingredient; your veterinarian determines whether and how they apply to your animal's treatment plan.

Constulose® is a commercial brand of lactulose, a synthetic disaccharide utilized in veterinary medicine as an osmotic laxative and ammonia reducer. It is a prescription medication available for use in dogs and cats, frequently considered by veterinarians for patients presented with chronic constipation or hepatic encephalopathy. At a pharmacological level, lactulose remains undigested until it reaches the colon, where bacteria break it down into organic acids. This process increases osmotic pressure, drawing water into the bowel to manage stool consistency and transition. In cases of liver disease, these organic acids manage the environment by acidifying colonic contents, which traps ammonia as ammonium ions and promotes its excretion. Your veterinarian will determine the clinical appropriateness of lactulose based on your pet's physical signs and diagnostic history.

Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.

Commonly observed effects following the administration of lactulose include localized digestive changes such as flatulence, abdominal cramping or diarrhea. Because it acts by drawing water into the gut, your veterinarian will monitor for signs of dehydration or electrolyte imbalances, especially with long-term use. Owners should monitor their pet for any unusual lethargy or significant changes in bowel habits and contact their veterinarian promptly with any concerns regarding their pet’s response. This medication is typically used with extra caution or avoided in patients with known diabetes mellitus, as it contains small amounts of free galactose and lactose. It is also carefully evaluated in pets with pre-existing electrolyte abnormalities. Significant interactions can occur if lactulose is administered concurrently with specific antacids or other laxatives that may interfere with its mechanism. Your veterinarian is the right person to provide guidance on the necessary duration of use to ensure the management approach remains suitable for your pet's metabolic needs.