Colchicine Capsule
Colchicine is a compounded formulation containing Colchicine, prepared by Mixlab for veterinary use. Available by prescription.
Use as directed by your veterinarian.
The uses and pharmacology described below reflect the FDA-approved labeling for this active ingredient; your veterinarian determines whether and how they apply to your animal's treatment plan.
Colchicine is an alkaloid derivative utilized in veterinary medicine primarily for the management of conditions involving systemic inflammation and fibrosis. It is a prescription medication available for use in dogs and cats, frequently considered by veterinarians for patients presented with Shar-Pei Fever or chronic hepatic and renal conditions where addressing collagen deposition is a clinical objective. At a pharmacological level, colchicine acts by binding to tubulin, which inhibits microtubule polymerization. This action disrupts several cellular processes, including the migration and activation of inflammatory cells like neutrophils. By managing these cellular activities, the medication provides a method for managing the progression of localized and systemic inflammatory responses. It is also discussed for its potential to manage the synthesis and secretion of serum amyloid A, a protein associated with amyloidosis. Your veterinarian will determine the clinical appropriateness of colchicine based on your pet’s diagnostic findings and breed-specific health history.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
Commonly observed effects following the administration of colchicine include localized digestive changes such as vomiting, diarrhea or a temporary decrease in appetite. Because it influences rapidly dividing cells, some animals may exhibit behavioral shifts including lethargy or, in rare cases, changes in hair coat. Owners should monitor their pet for any unusual digestive distress or significant changes in energy levels and contact their veterinarian promptly with any concerns. This medication is typically used with extra caution or avoided in patients with known severe renal or hepatic impairment, as these organs are involved in the clearance of the medication. It is also carefully evaluated in pets with pre-existing bone marrow suppression or cardiovascular disease. Significant interactions can occur if colchicine is administered concurrently with specific liver enzyme inhibitors or other medications that influence cellular function. Your veterinarian is the right person to provide guidance on the necessary duration of use and the most commonly considered monitoring schedule to ensure the management approach remains suitable for your pet's health status.
Yes. Colchicine is a prescription medication and can only be dispensed by a licensed pharmacy upon receipt of a valid authorization from a licensed veterinarian. Mixlab verifies all authorizations before any medication is prepared or shipped to your home.
Yes. While colchicine is available in commercial tablet formats, Mixlab specializes in compounding the active ingredient into customized strengths and flavored dosage forms—such as flavored oral liquids—to suit the specific needs of dogs and cats. The decision rests with the prescribing veterinarian.
Veterinarians discuss colchicine for Shar-Pei Fever because it manages the inflammatory cells and proteins that contribute to the fever episodes. By managing these physiological responses, the medication provides a method for addressing the frequency and severity of the condition's signs.
Your veterinarian will periodically monitor your pet's blood work, including kidney and liver function, to ensure the medication is being cleared properly. They will also provide guidance on watching for signs of digestive upset during the management course.
