Clopidogrel/Rivaroxaban Oral Suspension (Anhydrous)
Clopidogrel/Rivaroxaban is a compounded dual-action antithrombotic (blood thinner) medication prescribed for dogs and cats to prevent and treat dangerous blood clots. It combines an antiplatelet drug (which keeps platelets from sticking together) with a direct Factor Xa inhibitor anticoagulant (which stops the chemical cascade that forms clots). This aggressive combination therapy is utilized for high-risk cardiovascular conditions, such as preventing or treating aortic thromboembolism (saddle thrombus) in cats with heart disease or aortic thrombosis in dogs.
How to Give Anhydrous Oral Suspension
Oral Suspension (Anhydrous) is a liquid medication that does not contain water in its base. This might be an oil-based or other special base to help stabilize the medicine. It will look like a regular liquid medication, but often needs a good shake because the drug can settle. Here's how to give it:
- Shake well each time to mix the medication (5-10 seconds).
- Measure the dose using the syringe/dropper provided or one recommended by your vet. Insert the top of the oral syringe into the bottle adapter. Turn the bottle upside down and pull the plunger until the medicine reaches the volume required
- Hold your pet steady: a towel or helper can assist with squirmy pets.
- Administer the dose slowly into the side of the mouth. Allow small pauses if needed for swallowing.
- Raise the head slightly to help the medication go down and clean any spills with a little water or tissue.
- Praise your pet and offer a treat or water (unless advised against feeding right after).
- Clean the syringe with water immediately after use. Store the bottle as directed, out of sunlight.
- Consistency is key: Shake each time, measure accurately, and contact your vet if any issues arise.
This compounded formulation combines active ingredients from different drug classes: clopidogrel, an antiplatelet agent and rivaroxaban, a Factor Xa inhibitor anticoagulant. In compounding practice, clinicians may consider a combination like this to consolidate more than one medication into a single administration. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.
Clopidogrel inhibits platelet aggregation by blocking the platelet P2Y12 ADP receptor; rivaroxaban inhibits Factor Xa, a key step in the clotting cascade.
This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
Because both ingredients affect clotting, your veterinarian will individualize the preparation and monitor your animal closely. Watch for and promptly report any signs of bleeding — unusual bruising, blood in urine or stool or prolonged bleeding from minor injuries — and provide a complete medication list so interactions can be considered.
Yes. This is a prescription product and can only be dispensed by a licensed pharmacy after a valid prescription is received from a licensed veterinarian. Mixlab verifies every prescription before dispensing.
Yes. Mixlab can compound this combination in the strength and format your veterinarian specifies for your animal.
Each active contributes a different mechanism. Your veterinarian determines whether a combined preparation is appropriate for your animal's situation.
Your veterinarian will individualize the preparation and may recommend periodic monitoring to keep the plan appropriate for your pet.
