Clomicalm Tablet
Clomicalm is an FDA-approved preparation containing Clomicalm, for veterinary use. Available by prescription.
Clomicalm® is a commercial brand of clomipramine hydrochloride, a tricyclic antidepressant (TCA) utilized in veterinary medicine for the management of behavioral challenges. It is a prescription medication available for use in dogs, particularly when veterinarians seek to address multifaceted separation anxiety in conjunction with behavioral modification. At a pharmacological level, clomipramine acts as a selective inhibitor of serotonin reuptake, while also influencing norepinephrine reuptake. By blocking these reabsorption pathways, the medication increases the concentration of these neurotransmitters in the synaptic cleft. Serotonin and norepinephrine are chemical messengers associated with the regulation of emotional response, mood and reactivity. This increase in neurotransmitter availability provides a mechanism for managing the reactive state associated with separation distress. Your veterinarian will determine the clinical appropriateness of Clomicalm® based on your pet’s behavioral history and health status.
The actions described here reflect the product's FDA-approved labeling; your veterinarian determines the appropriate use for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring.
Commonly observed effects following the administration of Clomicalm® include mild sedation, temporary Coordination shifts (ataxia) or localized digestive changes such as vomiting or a decrease in appetite. Some animals may exhibit behavioral shifts including increased thirst or a change in sleep patterns. Because clomipramine has anticholinergic properties, it may influence tear production or heart rate in some patients. Owners should monitor their pet for any unusual behavioral changes or persistent digestive distress and contact their veterinarian promptly with any concerns. This medication is typically used with extra caution or avoided in patients with known cardiovascular disease, glaucoma or a history of seizures. It is also carefully evaluated in male dogs used for breeding, as it may influence sperm production. Significant interactions can occur if Clomicalm® is administered concurrently with MAOIs, tramadol or other serotonergic agents. It is important to never discontinue this medication abruptly; your veterinarian is the right person to provide guidance on the necessary duration of use and the proper tapering schedule to ensure the management approach remains suitable for your pet's needs.
Yes. Clomicalm is a prescription medication and can only be dispensed by a licensed pharmacy upon receipt of a valid authorization from a licensed veterinarian. Mixlab verifies all authorizations before any medication is prepared or shipped to your home.
Clomicalm is available as a commercial tablet. If your veterinarian determines that a customized strength or a specific flavored dosage form—such as a flavored oral liquid—better suits your dog's needs, Mixlab's compounding team can prepare that formulation with a valid prescription. The decision between commercial and compounded preparations rests with the prescribing veterinarian.
Veterinarians most commonly discuss Clomicalm as a component of a management plan for separation anxiety in dogs. It is typically used in combination with behavioral modification to manage the reactive state and help the pet feel more relaxed.
Veterinarians often discuss that it can take several weeks of consistent administration before the full physiological influence of Clomicalm is observed. Your veterinarian will provide guidance on what to expect during the initial weeks of the management approach and how to monitor your pet's progress.
