ChloramPHENICOL/KETOconazole/Betamethasone clEARmix Thermo Gel Otic (3mL Syringe)

How to Use clEARmix Thermo Gel Otic (Ear Medication)

This is a liquid ear medication that turns into a gel once it warms up in your pet’s ear, helping it stay in place and work effectively. It comes in a soft-tipped syringe for easy use.

Step-by-Step:

1. Keep it cool – Store in the fridge if instructed. Before using, hold the syringe in your hands for a minute so it’s not too cold, but don’t warm it too much.
2. Get your pet ready – Have them sit comfortably and gently lift the ear flap. A second person can help hold them still if needed.
3. Clean the ear (if advised) – Use a vet-approved ear cleaner and cotton ball. Wipe out any debris and let the ear dry.
4. Apply the medication – Take off the cap. Gently insert just the tip into the ear opening (not deep), and slowly press the plunger to deliver the full dose.
5. Massage the ear – Rub the base of the ear for 30 seconds. The liquid will turn into a gel as it warms, and massaging helps it spread inside the ear.
6. Let them shake it out – It’s normal! Wipe away any extra gel you see near the ear opening.
7. Reward your pet – Offer praise or a treat to keep the experience positive.
8. Store and clean up – Recap the syringe and refrigerate if needed. Wash your hands afterward.

This compounded formulation combines active ingredients from different drug classes: chloramphenicol, an antibiotic; ketoconazole, an azole antifungal; and betamethasone, a corticosteroid. In compounding practice, clinicians may consider a multi-ingredient preparation like this to address more than one aspect of a patient's physiology at once. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.

This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.

Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.

Commonly observed effects following the administration of this combination include localized changes at the application site, such as redness, itching or mild irritation. Because the formulation contains betamethasone, systemic absorption is possible, especially with long-term use or application over large surface areas; your veterinarian will monitor for signs of corticosteroid influence such as increased thirst or changes in appetite. In the context of ear administration, ensuring the eardrum (tympanic membrane) is intact is a high-priority clinical consideration to help reduce potential inner ear sensitivity. Owners should watch for behavioral shifts including a head tilt, loss of balance or sudden changes in hearing and contact their veterinarian promptly with any concerns.

This medication is typically used with extra caution or avoided in patients with known hypersensitivity to any of the active ingredients or those presented with viral skin infections. Because chloramphenicol is included in this prescription, humans handling the medication should follow specific safety precautions, such as wearing gloves during administration, as directed by their veterinarian. Before starting a protocol, ensure your veterinarian has a complete history of all other medications your pet is receiving. Your veterinarian is the right person to provide guidance on the necessary duration of use and the proper monitoring schedule to ensure the management approach remains suitable for your pet's recovery.