ChloramPHENICOL/Doxycycline (as Hyclate) clEARmix Lanolin Otic (3mL Syringe)
ChloramPHENICOL/Doxycycline (as Hyclate) is a compounded formulation containing chloramphenicol and doxycycline (as hyclate), prepared by Mixlab for veterinary use. Available by prescription.
How to Use clEARmix Lanolin Otic (Ear Medication)
This is a thick ear ointment used to treat ear infections. It comes in a pre-filled syringe with a soft tip, making it easier to apply and designed to stay in your pet’s ear longer.
Step-by-Step: 1. Warm the syringe – If it’s cold, hold it in your hands for a minute to soften the ointment. Do not microwave. 2. Position your pet – Have them sit in a comfy spot. You may need someone to gently help hold them. Lift their ear flap straight up. 3. Clean the ear (if needed) – Only if your vet told you to. Use a vet-approved ear cleaner and cotton ball—never a Q-tip deep in the ear. Let the ear dry. 4. Apply the medication – Remove the cap, then gently insert just the tip of the syringe into the ear opening. Don’t push in deep. 5. Dispense slowly – Press the plunger gently to apply the full dose or the amount your vet prescribed. 6. Massage the ear – Rub the base of the ear for about 30 seconds to help the medication spread. 7. Let them shake – It’s normal! Wipe off any excess with a tissue or cloth. 8. Reward your pet – Give them praise and maybe a treat to make it a positive experience. 9. Store the rest – If there’s more medication left, recap the syringe and store at room temp. Wash your hands after use.
This compounded formulation combines chloramphenicol, an antibiotic, with doxycycline, a tetracycline antibiotic — two different drug classes. In compounding practice, clinicians may consider a combination like this for a multi-targeted approach. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.
This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
Commonly observed effects following the administration of chlorambucil/doxycycline include localized digestive changes such as vomiting, diarrhea or a temporary decrease in appetite. A high-priority clinical consideration for chloramphenicol is its influence on bone marrow function; your veterinarian will direct periodic blood work to monitor for reversible bone marrow suppression. Owners should watch for behavioral shifts including lethargy or unusual weakness and contact their veterinarian promptly with any concerns.
This medication is typically used with extra caution or avoided in patients with known severe hepatic impairment or pre-existing blood disorders. Doxycycline hyclate is associated with localized irritation if a tablet becomes lodged in the esophagus, so your veterinarian may recommend following administration with a small amount of water or food. Because chloramphenicol can interfere with the metabolism of other medications, a complete history of all other prescriptions your pet is receiving is essential. Furthermore, humans handling chloramphenicol should follow specific safety precautions, such as wearing gloves, as directed by their veterinarian. Your veterinarian is the right person to provide guidance on the necessary monitoring frequency and the proper administration schedule to ensure the management approach remains suitable for your pet's recovery.
Yes. Chloramphenicol/doxycycline is a combination of potent antibiotics and can only be dispensed by a licensed pharmacy upon receipt of a valid authorization from a licensed veterinarian. Mixlab verifies all authorizations before any medication is prepared or shipped to your home.
Yes. Because this specific dual-antibiotic combination is not available as a single commercial product, Mixlab specializes in compounding it into customized strengths and flavored dosage forms—such as oral liquids or capsules—to suit the specific needs of dogs and cats. The decision to use a compounded formulation rests with the prescribing veterinarian.
Veterinarians may consider combining these ingredients so the preparation can act through more than one mechanism at once — here, it focuses on antibacterial action. Your veterinarian determines whether this multi-targeted approach is appropriate for your pet.
Chloramphenicol requires careful handling; your veterinarian will likely recommend wearing unpowdered disposable gloves when administering the medication to your pet. You should also wash your hands thoroughly after handling the medication and avoid direct contact with your pet's waste during the treatment period.
