Betamethasone/ChloramPHENICOL/KETOconazole clEARmix Lanolin Otic (3mL Syringe)

How to Use clEARmix Lanolin Otic (Ear Medication)

This is a thick ear ointment used to treat ear infections. It comes in a pre-filled syringe with a soft tip, making it easier to apply and designed to stay in your pet’s ear longer.

Step-by-Step: 1. Warm the syringe – If it’s cold, hold it in your hands for a minute to soften the ointment. Do not microwave. 2. Position your pet – Have them sit in a comfy spot. You may need someone to gently help hold them. Lift their ear flap straight up. 3. Clean the ear (if needed) – Only if your vet told you to. Use a vet-approved ear cleaner and cotton ball—never a Q-tip deep in the ear. Let the ear dry. 4. Apply the medication – Remove the cap, then gently insert just the tip of the syringe into the ear opening. Don’t push in deep. 5. Dispense slowly – Press the plunger gently to apply the full dose or the amount your vet prescribed. 6. Massage the ear – Rub the base of the ear for about 30 seconds to help the medication spread. 7. Let them shake – It’s normal! Wipe off any excess with a tissue or cloth. 8. Reward your pet – Give them praise and maybe a treat to make it a positive experience. 9. Store the rest – If there’s more medication left, recap the syringe and store at room temp. Wash your hands after use.

This compounded formulation combines active ingredients from different drug classes: betamethasone, a corticosteroid; chloramphenicol, an antibiotic; and ketoconazole, an azole antifungal. In compounding practice, clinicians may consider a multi-ingredient preparation like this to address more than one aspect of a patient's physiology at once. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.

At a pharmacological level, this medication functions through three distinct mechanisms. Betamethasone is a glucocorticoid that acts by inducing lipocortins, which inhibit phospholipase A2; this may help address the release of arachidonic acid and the subsequent synthesis of inflammatory mediators like prostaglandins and leukotrienes. Chloramphenicol is a broad-spectrum antibiotic that binds to the 50S ribosomal subunit of susceptible bacteria, which may help address the process of protein synthesis and may help reduce bacterial replication. Ketoconazole acts by inhibiting the fungal enzyme cytochrome P450 14-alpha-demethylase, a necessary step in the synthesis of ergosterol; this inhibition may help address the maintenance of the fungal cell membrane. Your veterinarian will determine the clinical appropriateness of this combination based on results from localized diagnostic testing such as ear or skin cytology.

This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.

Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.

Commonly observed effects following the administration of this topical combination include localized redness or sensitivity at the application site. Because corticosteroids like betamethasone can be absorbed systemically through the skin or ear canal, owners should watch for behavioral shifts such as increased thirst (polydipsia) or increased urination (polyuria). A high-priority clinical consideration for ear applications is the integrity of the tympanic membrane (eardrum); your veterinarian will perform a thorough examination to ensure it is intact before directing use. Owners should watch for signs of head tilting, dizziness or sudden hearing changes and contact their veterinarian promptly if these occur.

This medication is typically used with extra caution or avoided in patients with a known hypersensitivity to any of the active ingredients or in those with pre-existing viral infections at the site of application. It is also carefully evaluated in pregnant or lactating animals due to the potential for systemic corticosteroid absorption. Before starting any new topical protocol, ensure your veterinarian has a complete history of all other ear or skin products your pet is receiving to avoid localized interactions. Your veterinarian is the right person to provide guidance on the necessary duration of use and the proper method of administration to ensure the management approach remains suitable for your pet's individual health status.