Amlodipine/Benazepril Transdermal Pen (6mL)

A transdermal pen is a simple way to give your pet medicine through their skin—usually used for cats by applying gel to the inside of their ear.

Step-by-Step:

1. Get the pen ready – Twist the pen to dispense a small amount of gel. If it’s your first time, you will need to “prime” it first (the gel should be flush with the edge of the tip)
2. Wear gloves – Always use a disposable glove or finger cot so the medication doesn’t absorb into your skin.
3. Twist to dose – Follow the pen’s directions (like two full twists) to get the right amount of gel out. Always click in a clockwise direction, clicking counter-clockwise will stop you
4. Pick the spot – Apply to a hairless area, usually the inside of your cat’s ear. Make sure the area is clean and dry.
5. Apply the gel – Dab the gel directly with the pen or use your gloved finger to rub it in gently. Avoid the ear canal.
6. Let it dry – It usually dries in a minute or two. Try to keep your pet from rubbing it off.
7. Recap the pen – This keeps the medication fresh.
8. Wash your hands – Even if you wore gloves, wash thoroughly after.
9. Reward your pet – A treat helps make it a stress-free routine!
10. Store properly – Keep at room temp, away from sunlight. Track doses so you know when it’s time to refill.

Important: Only apply where your vet has directed—usually hairless areas. Never apply over fur or broken skin. Keep other pets from licking the area until it’s dry.

This compounded formulation combines amlodipine, a calcium channel blocker, with benazepril, an ACE inhibitor — two different drug classes. In compounding practice, clinicians may consider a combination like this for a multi-targeted approach. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.

At a pharmacological level, this medication functions through two distinct mechanisms. Amlodipine acts by inhibiting the movement of calcium ions into vascular smooth muscle cells, which results in the relaxation of the peripheral arteries. Benazepril is a prodrug that is converted to benazeprilat, which may help address the conversion of angiotensin I to angiotensin II. Because angiotensin II is a potent vasoconstrictor and a stimulator of aldosterone release, inhibiting its production may be part of a management approach for systemic vascular resistance and may help address the workload on the heart. Your veterinarian will determine whether this combination is appropriate based on your pet’s diagnostic testing results, blood pressure readings and overall metabolic status.

This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.

Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.

Commonly observed effects of amlodipine/benazepril administration include lethargy, a decrease in appetite and localized digestive changes such as vomiting or loose stools. Because this medication influences systemic circulation, some pets may experience hypotension (low blood pressure), which can manifest as significant weakness or disorientation. Your veterinarian will monitor for shifts in renal parameters, such as BUN and creatinine, through periodic blood work to ensure the medication remains suitable for your pet's health status. Owners should watch for signs of persistent lethargy or unusual weakness and contact their veterinarian promptly if these behavioral shifts occur.

This medication is typically used with extra caution or avoided in patients with known severe sodium depletion, dehydration or pre-existing low blood pressure. It is also carefully evaluated in pregnant or lactating animals, as ACE inhibitors are associated with developmental considerations in fetal health. Before starting a protocol, ensure your veterinarian has a complete history of all other prescriptions and supplements your pet is receiving, as significant interactions can occur with certain diuretics, non-steroidal anti-inflammatory medications (NSAIDs) or other heart medications. Your veterinarian is the right person to provide guidance on the necessary duration of use and the most commonly considered monitoring plan for your pet's individual needs.