Amlodipine/Atenolol Transdermal Pen (1.5mL)
Amlodipine/Atenolol is a compounded formulation containing Amlodipine, Atenolol, prepared by Mixlab for veterinary use. Available by prescription.
A transdermal pen is a simple way to give your pet medicine through their skin—usually used for cats by applying gel to the inside of their ear.
Step-by-Step:
- Get the pen ready – Twist the pen to dispense a small amount of gel. If it’s your first time, you will need to “prime” it first (the gel should be flush with the edge of the tip)
- Wear gloves – Always use a disposable glove or finger cot so the medication doesn’t absorb into your skin.
- Twist to dose – Follow the pen’s directions (like two full twists) to get the right amount of gel out. Always click in a clockwise direction, clicking counter-clockwise will stop you
- Pick the spot – Apply to a hairless area, usually the inside of your cat’s ear. Make sure the area is clean and dry.
- Apply the gel – Dab the gel directly with the pen or use your gloved finger to rub it in gently. Avoid the ear canal.
- Let it dry – It usually dries in a minute or two. Try to keep your pet from rubbing it off.
- Recap the pen – This keeps the medication fresh.
- Wash your hands – Even if you wore gloves, wash thoroughly after.
- Reward your pet – A treat helps make it a stress-free routine!
- Store properly – Keep at room temp, away from sunlight. Track doses so you know when it’s time to refill.
Important: Only apply where your vet has directed—usually hairless areas. Never apply over fur or broken skin. Keep other pets from licking the area until it’s dry.
This compounded formulation combines amlodipine, a calcium channel blocker, with atenolol, a beta-blocker — two different drug classes. In compounding practice, clinicians may consider a combination like this for a multi-targeted approach. Your veterinarian determines whether it is appropriate based on your animal's diagnostic findings.
The mechanism of action involves the synergistic effects of both medications. Amlodipine acts as a calcium channel blocker that promotes peripheral vasodilation by inhibiting the influx of calcium ions into vascular smooth muscle cells. This process leads to a reduction in systemic vascular resistance. Conversely, atenolol is a cardioselective beta-1 adrenergic antagonist that acts on the heart muscle to decrease heart rate and contractility. By blocking the effects of adrenaline on beta receptors, atenolol may be part of a management approach for heart rate and may help address the workload on the cardiac muscle. Your veterinarian will determine the appropriate ratio and frequency for this combination based on your pet’s specific diagnostic readings and cardiovascular health status.
This description reflects the general pharmacology of the active ingredient's drug class; your veterinarian determines whether this approach is appropriate for your animal.
Prescription only. Use only under the direction of a licensed veterinarian. This information is not a substitute for veterinary diagnosis, prescribing or monitoring. Compounded drugs are not approved by the FDA for safety or effectiveness.
Commonly observed effects of this combination include lethargy, decreased appetite and a slower-than-normal heart rate (bradycardia). Because both medications impact blood pressure, owners should watch for signs of hypotension, such as weakness, wobbliness or fainting. In some feline patients, gingival hyperplasia—an overgrowth of the gum tissue—has been noted with long-term use of calcium channel blockers. If you observe any unexpected changes in your pet’s behavior, activity levels or appearance, contact your veterinarian promptly for a clinical evaluation.
This medication is typically used with extra caution or avoided in patients with certain types of heart block, severe the relevant cardiac condition or significant asthma, as beta-blockers can affect airway resistance. It is also used carefully in patients with known liver or kidney impairment, as these organs are responsible for the metabolism and excretion of the prescriptions. Sudden discontinuation of atenolol can lead to a rapid increase in heart rate or blood pressure, so it is essential to follow your veterinarian's guidance regarding any changes to the treatment plan. Always provide a full list of your pet's other medications and supplements to your veterinarian before starting this combination to avoid potential interactions.
Yes. Amlodipine/atenolol is a combination of prescription medications and can only be dispensed by a licensed pharmacy upon receipt of a valid prescription from a licensed veterinarian. Mixlab verifies all prescriptions before dispensing to ensure patient safety and regulatory compliance.
Yes, this specific combination is frequently compounded because it allows two medications to be administered as a single dose. Mixlab can prepare this in various formats, such as flavored liquids or chews, which can be helpful for pets that are difficult to pill or require customized strength ratios as determined by their veterinarian.
Veterinarians often select a combination of amlodipine and atenolol to take advantage of different pharmacological pathways. This approach may be considered when a patient requires both heart rate management and blood pressure reduction, or when one medication alone has not reached the desired clinical objectives.
If a dose is missed, you should consult your veterinarian for specific instructions, as the timing of cardiovascular medications is important for maintaining stable blood pressure. Generally, you should not "double up" on doses; however, your veterinarian will provide a protocol tailored to your pet's health history.
